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dc.contributor.authorPahovnik, David
dc.contributor.authorHadjichristidis, Nikos
dc.date.accessioned2017-01-02T08:42:40Z
dc.date.available2017-01-02T08:42:40Z
dc.date.issued2015-09-01
dc.identifier.citationPahovnik D, Hadjichristidis N (2015) Ring-Opening Polymerization of N-Carboxyanhydrides for Preparation of Polypeptides and Polypeptide-Based Hybrid Materials with Various Molecular Architectures. Anionic Polymerization: 307–337. Available: http://dx.doi.org/10.1007/978-4-431-54186-8_6.
dc.identifier.doi10.1007/978-4-431-54186-8_6
dc.identifier.urihttp://hdl.handle.net/10754/622245
dc.description.abstractDifferent synthetic approaches utilizing ring-opening polymerization of N-carboxyanhydrides for preparation of polypeptide and polypeptide-based hybrid materials with various molecular architectures are described. An overview of polymerization mechanisms using conventional (various amines) as well as some recently developed initiators (hexamethyldisilazane, N-heterocyclic persistent carbenes, etc.) is presented, and their benefits and drawbacks for preparation of polypeptides with well-defined chain lengths and chain-end functionality are discussed. Recent examples from literature are used to illustrate different possibilities for synthesis of pure polypeptide materials with different molecular architectures bearing various functional groups, which are introduced either by modification of amino acids, before they are transformed into corresponding Ncarboxyanhydrides, or by post-polymerization modifications using protective groups and/or orthogonal functional groups. Different approaches for preparation of polypeptide-based hybrid materials are discussed as well using examples from recent literature. Syntheses of simple block copolymers or copolymers with more complex molecular architectures (graft and star copolymers) as well as modifications of nanoparticles and other surfaces with polypeptides are described.
dc.publisherSpringer Nature
dc.subjectHybrid materials
dc.subjectMolecular architectures
dc.subjectN-carboxyanhydrides
dc.subjectPolypeptides
dc.subjectRing-opening polymerization
dc.titleRing-Opening Polymerization of N-Carboxyanhydrides for Preparation of Polypeptides and Polypeptide-Based Hybrid Materials with Various Molecular Architectures
dc.typeBook Chapter
dc.contributor.departmentChemical Science Program
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentPolymer Synthesis Laboratory
dc.identifier.journalAnionic Polymerization
kaust.personPahovnik, David
kaust.personHadjichristidis, Nikos
dc.date.published-online2015-09-01
dc.date.published-print2015


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