TcoF-DB v2: update of the database of human and mouse transcription co-factors and transcription factor interactions
Type
ArticleKAUST Department
Computational Bioscience Research Center (CBRC)Computer Science Program
Applied Mathematics and Computational Science Program
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
KAUST Grant Number
URF/1/1976-02Date
2016-10-26Online Publication Date
2016-10-26Print Publication Date
2017-01-04Permanent link to this record
http://hdl.handle.net/10754/622045
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Show full item recordAbstract
Transcription factors (TFs) play a pivotal role in transcriptional regulation, making them crucial for cell survival and important biological functions. For the regulation of transcription, interactions of different regulatory proteins known as transcription co-factors (TcoFs) and TFs are essential in forming necessary protein complexes. Although TcoFs themselves do not bind DNA directly, their influence on transcriptional regulation and initiation, although indirect, has been shown to be significant, with the functionality of TFs strongly influenced by the presence of TcoFs. In the TcoF-DB v2 database, we collect information on TcoFs. In this article, we describe updates and improvements implemented in TcoF-DB v2. TcoF-DB v2 provides several new features that enables exploration of the roles of TcoFs. The content of the database has significantly expanded, and is enriched with information from Gene Ontology, biological pathways, diseases and molecular signatures. TcoF-DB v2 now includes many more TFs; has substantially increased the number of human TcoFs to 958, and now includes information on mouse (418 new TcoFs). TcoF-DB v2 enables the exploration of information on TcoFs and allows investigations into their influence on transcriptional regulation in humans and mice. TcoF-DB v2 can be accessed at http://tcofdb.org/.Citation
Schmeier S, Alam T, Essack M, Bajic VB (2016) TcoF-DB v2: update of the database of human and mouse transcription co-factors and transcription factor interactions. Nucleic Acids Research: gkw1007. Available: http://dx.doi.org/10.1093/nar/gkw1007.Sponsors
King Abdullah University of Science and Technology (KAUST) base research fund (to T.A. and V.B.B.); KAUST Office of Sponsored Research (OSR) [URF/1/1976-02 to M.E.]. Funding for open access charge: KAUST.Publisher
Oxford University Press (OUP)Journal
Nucleic Acids ResearchAdditional Links
https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkw1007ae974a485f413a2113503eed53cd6c53
10.1093/nar/gkw1007
Scopus Count
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