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dc.contributor.authorOmar, Haneen
dc.contributor.authorCroissant, Jonas G.
dc.contributor.authorAlamoudi, Kholod
dc.contributor.authorAlsaiari, Shahad K.
dc.contributor.authorAlradwan, Ibrahim
dc.contributor.authorMajrashi, Majed A.
dc.contributor.authorAnjum, Dalaver H.
dc.contributor.authorMartins, Patricia
dc.contributor.authorMoosa, Basem
dc.contributor.authorAlmalik, Abdulaziz
dc.contributor.authorKhashab, Niveen M.
dc.date.accessioned2016-11-30T08:43:10Z
dc.date.available2016-11-30T08:43:10Z
dc.date.issued2016-11-29
dc.identifier.citationOmar H, Croissant JG, Alamoudi K, Alsaiari S, Alradwan I, et al. (2016) Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery. Journal of Controlled Release. Available: http://dx.doi.org/10.1016/j.jconrel.2016.11.032.
dc.identifier.issn0168-3659
dc.identifier.doi10.1016/j.jconrel.2016.11.032
dc.identifier.urihttp://hdl.handle.net/10754/621898
dc.description.abstractThe delivery of large cargos of diameter above 15 nm for biomedical applications has proved challenging since it requires biocompatible, stably-loaded, and biodegradable nanomaterials. In this study, we describe the design of biodegradable silica-iron oxide hybrid nanovectors with large mesopores for large protein delivery in cancer cells. The mesopores of the nanomaterials spanned from 20 to 60 nm in diameter and post-functionalization allowed the electrostatic immobilization of large proteins (e.g. mTFP-Ferritin, ~ 534 kDa). Half of the content of the nanovectors was based with iron oxide nanophases which allowed the rapid biodegradation of the carrier in fetal bovine serum and a magnetic responsiveness. The nanovectors released large protein cargos in aqueous solution under acidic pH or magnetic stimuli. The delivery of large proteins was then autonomously achieved in cancer cells via the silica-iron oxide nanovectors, which is thus a promising for biomedical applications.
dc.publisherElsevier BV
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0168365916312251
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Journal of Controlled Release. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Controlled Release, 29 November 2016. DOI: 10.1016/j.jconrel.2016.11.032
dc.subjectsilica nanoparticles
dc.subjectmagnetic nanoparticles
dc.subjectprotein delivery
dc.subjectbiodegradable nanoparticles
dc.subjectpH triggered delivery
dc.titleBiodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery
dc.typeArticle
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentBioscience Program
dc.contributor.departmentChemical Science Program
dc.contributor.departmentElectron Microscopy
dc.contributor.departmentImaging and Characterization Core Lab
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Division
dc.identifier.journalJournal of Controlled Release
dc.eprint.versionPost-print
dc.contributor.institutionLife sciences and Environment Research Institute, Center of Excellence in Nanomedicine (CENM), King Abdulaziz City for Science and Technology (KACST), Riyadh 11461, Saudi Arabia
kaust.personOmar, Haneen
kaust.personCroissant, Jonas G.
kaust.personAlamoudi, Kholod
kaust.personAlsaiari, Shahad K.
kaust.personAnjum, Dalaver H.
kaust.personMartins, Patricia
kaust.personMoosa, Basem
kaust.personKhashab, Niveen M.
refterms.dateFOA2017-11-29T00:00:00Z
dc.date.published-online2016-11-29
dc.date.published-print2017-08


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