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dc.contributor.authorTanaka, Hiroo
dc.contributor.authorYamamoto, Yasuko
dc.contributor.authorKashihara, Hiroka
dc.contributor.authorYamazaki, Yuji
dc.contributor.authorTani, Kazutoshi
dc.contributor.authorFujiyoshi, Yoshinori
dc.contributor.authorMineta, Katsuhiko
dc.contributor.authorTakeuchi, Kosei
dc.contributor.authorTamura, Atsushi
dc.contributor.authorTsukita, Sachiko
dc.date.accessioned2016-11-03T13:23:32Z
dc.date.available2016-11-03T13:23:32Z
dc.date.issued2016-01-04
dc.identifier.citationTanaka H, Yamamoto Y, Kashihara H, Yamazaki Y, Tani K, et al. (2016) Claudin-21 Has a Paracellular Channel Role at Tight Junctions. Mol Cell Biol 36: 954–964. Available: http://dx.doi.org/10.1128/mcb.00758-15.
dc.identifier.issn0270-7306
dc.identifier.issn1098-5549
dc.identifier.pmid26729464
dc.identifier.doi10.1128/mcb.00758-15
dc.identifier.urihttp://hdl.handle.net/10754/621721
dc.description.abstractClaudin protein family members, of which there are at least 27 in humans and mice, polymerize to form tight junctions (TJs) between epithelial cells, in a tissue- and developmental stage-specific manner. Claudins have a paracellular barrier function. In addition, certain claudins function as paracellular channels for small ions and/or solutes by forming selective pores at the TJs, although the specific claudins involved and their functional mechanisms are still in question. Here we show for the first time that claudin-21, which is more highly expressed in the embryonic than the postnatal stages, acts as a paracellular channel for small cations, such as Na+, similar to the typical channel-type claudins claudin-2 and -15. Claudin-21 also allows the paracellular passage of larger solutes. Our findings suggest that claudin-21-based TJs allow the passage of small and larger solutes by both paracellular channel-based and some additional mechanisms. © 2016, American Society for Microbiology. All Rights Reserved.
dc.description.sponsorshipMinistry of Education, Culture, Sports, Science, and Technology (MEXT) provided funding to Sachiko Tsukita under grant number 24247037. Ministry of Education, Culture, Sports, Science, and Technology (MEXT) provided funding to Yoshinori Fujiyoshi under grant number 22227004. Ministry of Education, Culture, Sports, Science, and Technology (MEXT) provided funding to Kazutoshi Tani under grant number 26440024. Ministry of Education, Culture, Sports, Science, and Technology (MEXT) provided funding to Kosei Takeuchi. Core Research for Evolutional Science and Technology, Japan Science and Technology Agency (CREST, JST) provided funding to Sachiko Tsukita.
dc.publisherAmerican Society for Microbiology
dc.titleClaudin-21 Has a Paracellular Channel Role at Tight Junctions
dc.typeArticle
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.identifier.journalMolecular and Cellular Biology
dc.contributor.institutionGraduate School of Medicine/Frontier Bioscience, Osaka University, Suita, Osaka, Japan
dc.contributor.institutionGraduate School of Medicine, Kyoto University, Kyoto, Japan
dc.contributor.institutionLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, United States
dc.contributor.institutionCellular and Structural Physiology Institute (CeSPI), Nagoya University, Nagoya, Japan
dc.contributor.institutionDepartment of Basic Medical Science, Graduate School of Pharmaceutical Science, Nagoya University, Nagoya, Japan
dc.contributor.institutionDepartment of Biology, School of Medicine, Aichi Medical University, Nagakute, Aichi, Japan
kaust.personMineta, Katsuhiko
dc.date.published-online2016-01-04
dc.date.published-print2016-03-15


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