Cooperative organocatalysis of Mukaiyama-type aldol reactions by thioureas and nitro compounds
Type
ArticleKAUST Department
Chemical Science ProgramKAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Date
2016Permanent link to this record
http://hdl.handle.net/10754/621695
Metadata
Show full item recordAbstract
A unique organocatalytic system for Mukaiyama-type aldol reactions based on the cooperative action of nitro compounds and thioureas has been identified. This system is compatible with a wide range of substrates and does not require low temperatures, inert atmospheres, or an aqueous workup. A catalytic mechanism based on nitro group-mediated silyl cation transfer has been proposed. © The Royal Society of Chemistry 2016.Citation
Bukhryakov KV, Desyatkin VG, Rodionov VO (2016) Cooperative organocatalysis of Mukaiyama-type aldol reactions by thioureas and nitro compounds. Chem Commun 52: 7576–7579. Available: http://dx.doi.org/10.1039/c6cc01984f.Sponsors
This research was supported by King Abdullah University of Science and Technology (KAUST). We are grateful to Dr Xianrong Guo (KAUST) for his assistance with <SUP>29</SUP>Si NMR, Dr Batian Chen (KAUST) for help with DFT calculations, and Sarah Almahdali (KAUST) for help with preparing the manuscript.Publisher
Royal Society of Chemistry (RSC)Journal
Chemical CommunicationsPubMed ID
27216276ae974a485f413a2113503eed53cd6c53
10.1039/c6cc01984f
Scopus Count
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