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dc.contributor.authorBüchel, Gabriel E.
dc.contributor.authorCarney, Brandon
dc.contributor.authorShaffer, Travis M.
dc.contributor.authorTang, Jun
dc.contributor.authorAustin, Christine
dc.contributor.authorArora, Manish
dc.contributor.authorZeglis, Brian M.
dc.contributor.authorGrimm, Jan
dc.contributor.authorEppinger, Jörg
dc.contributor.authorReiner, Thomas
dc.date.accessioned2016-11-03T13:22:41Z
dc.date.available2016-11-03T13:22:41Z
dc.date.issued2016-08-03
dc.identifier.citationBüchel GE, Carney B, Shaffer TM, Tang J, Austin C, et al. (2016) Near-Infrared Intraoperative Chemiluminescence Imaging. ChemMedChem 11: 1978–1982. Available: http://dx.doi.org/10.1002/cmdc.201600301.
dc.identifier.issn1860-7179
dc.identifier.pmid27471800
dc.identifier.doi10.1002/cmdc.201600301
dc.identifier.urihttp://hdl.handle.net/10754/621683
dc.description.abstractIntraoperative imaging technologies recently entered the operating room, and their implementation is revolutionizing how physicians plan, monitor, and perform surgical interventions. In this work, we present a novel surgical imaging reporter system: intraoperative chemiluminescence imaging (ICI). To this end, we have leveraged the ability of a chemiluminescent metal complex to generate near-infrared light upon exposure to an aqueous solution of Ce4+ in the presence of reducing tissue or blood components. An optical camera spatially resolves the resulting photon flux. We describe the construction and application of a prototype imaging setup, which achieves a detection limit as low as 6.9pmolcm-2 of the transition-metal-based ICI agent. As a proof of concept, we use ICI for the invivo detection of our transition metal tracer following both systemic and subdermal injections. The very high signal-to-noise ratios make ICI an interesting candidate for the development of new intraoperative imaging technologies. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.description.sponsorshipKing Abdullah University of Science and Technology
dc.description.sponsorshipUS National Institutes of Health (NIH)[P30 CA008748-48, R01CA183953, R01A183953, 4R00A178205-02, K25 EB016673, R01EB014944, R21 CA191679]
dc.description.sponsorshipMSKCC Center for Molecular Imaging and Nanotechnology
dc.description.sponsorshipTow Foundation
dc.description.sponsorshipMSKCC Experimental Therapeutics Center
dc.description.sponsorshipNational Science Foundation Integrative Graduate Education and Research Traineeship[IGERT 0965983]
dc.publisherWiley-Blackwell
dc.subjectChemiluminescence
dc.titleNear-Infrared Intraoperative Chemiluminescence Imaging
dc.typeArticle
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.identifier.journalChemMedChem
dc.contributor.institutionDepartment of Radiology; Memorial Sloan Kettering Cancer Center; New York NY 10065 USA
dc.contributor.institutionDepartment of Chemistry; Hunter College and PhD Program in Chemistry; The Graduate Center of the; City University of New York; New York NY 10018 USA
dc.contributor.institutionMolecular Pharmacology Program; Memorial Sloan Kettering Cancer Center; 1275 York Avenue New York NY 10065 USA
dc.contributor.institutionDepartment of Preventive Medicine; Icahn School of Medicine at Mount Sinai; New York NY 10029 USA
dc.contributor.institutionDepartment of Radiology; Weill Cornell Medical College; New York NY 10065 USA
dc.contributor.institutionProgram of Pharmacology; Weill Cornell Medical College; New York NY 10065 USA
kaust.personBüchel, Gabriel E.
kaust.personEppinger, Jörg


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