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    Near-Infrared Intraoperative Chemiluminescence Imaging

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    Type
    Article
    Authors
    Büchel, Gabriel E. cc
    Carney, Brandon
    Shaffer, Travis M.
    Tang, Jun
    Austin, Christine
    Arora, Manish
    Zeglis, Brian M.
    Grimm, Jan
    Eppinger, Jörg cc
    Reiner, Thomas cc
    KAUST Department
    Biological & Organometallic Catalysis Laboratories
    Chemical Science Program
    KAUST Catalysis Center (KCC)
    Physical Science and Engineering (PSE) Division
    Date
    2016-08-03
    Online Publication Date
    2016-07-29
    Print Publication Date
    2016-09-20
    Embargo End Date
    2017-08-03
    Permanent link to this record
    http://hdl.handle.net/10754/621683
    
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    Abstract
    Intraoperative imaging technologies recently entered the operating room, and their implementation is revolutionizing how physicians plan, monitor, and perform surgical interventions. In this work, we present a novel surgical imaging reporter system: intraoperative chemiluminescence imaging (ICI). To this end, we have leveraged the ability of a chemiluminescent metal complex to generate near-infrared light upon exposure to an aqueous solution of Ce4+ in the presence of reducing tissue or blood components. An optical camera spatially resolves the resulting photon flux. We describe the construction and application of a prototype imaging setup, which achieves a detection limit as low as 6.9pmolcm-2 of the transition-metal-based ICI agent. As a proof of concept, we use ICI for the invivo detection of our transition metal tracer following both systemic and subdermal injections. The very high signal-to-noise ratios make ICI an interesting candidate for the development of new intraoperative imaging technologies. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Citation
    Büchel GE, Carney B, Shaffer TM, Tang J, Austin C, et al. (2016) Near-Infrared Intraoperative Chemiluminescence Imaging. ChemMedChem 11: 1978–1982. Available: http://dx.doi.org/10.1002/cmdc.201600301.
    Sponsors
    King Abdullah University of Science and Technology
    US National Institutes of Health (NIH)[P30 CA008748-48, R01CA183953, R01A183953, 4R00A178205-02, K25 EB016673, R01EB014944, R21 CA191679]
    MSKCC Center for Molecular Imaging and Nanotechnology
    Tow Foundation
    MSKCC Experimental Therapeutics Center
    National Science Foundation Integrative Graduate Education and Research Traineeship[IGERT 0965983]
    Publisher
    Wiley
    Journal
    ChemMedChem
    DOI
    10.1002/cmdc.201600301
    PubMed ID
    27471800
    Additional Links
    http://europepmc.org/articles/pmc5061038?pdf=render
    ae974a485f413a2113503eed53cd6c53
    10.1002/cmdc.201600301
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Chemical Science Program; KAUST Catalysis Center (KCC)

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