Type
ArticleAuthors
Büchel, Gabriel E.
Carney, Brandon
Shaffer, Travis M.
Tang, Jun
Austin, Christine
Arora, Manish
Zeglis, Brian M.
Grimm, Jan
Eppinger, Jörg

Reiner, Thomas

KAUST Department
Biological & Organometallic Catalysis LaboratoriesChemical Science Program
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Date
2016-08-03Online Publication Date
2016-07-29Print Publication Date
2016-09-20Embargo End Date
2017-08-03Permanent link to this record
http://hdl.handle.net/10754/621683
Metadata
Show full item recordAbstract
Intraoperative imaging technologies recently entered the operating room, and their implementation is revolutionizing how physicians plan, monitor, and perform surgical interventions. In this work, we present a novel surgical imaging reporter system: intraoperative chemiluminescence imaging (ICI). To this end, we have leveraged the ability of a chemiluminescent metal complex to generate near-infrared light upon exposure to an aqueous solution of Ce4+ in the presence of reducing tissue or blood components. An optical camera spatially resolves the resulting photon flux. We describe the construction and application of a prototype imaging setup, which achieves a detection limit as low as 6.9pmolcm-2 of the transition-metal-based ICI agent. As a proof of concept, we use ICI for the invivo detection of our transition metal tracer following both systemic and subdermal injections. The very high signal-to-noise ratios make ICI an interesting candidate for the development of new intraoperative imaging technologies. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Citation
Büchel GE, Carney B, Shaffer TM, Tang J, Austin C, et al. (2016) Near-Infrared Intraoperative Chemiluminescence Imaging. ChemMedChem 11: 1978–1982. Available: http://dx.doi.org/10.1002/cmdc.201600301.Sponsors
King Abdullah University of Science and TechnologyUS National Institutes of Health (NIH)[P30 CA008748-48, R01CA183953, R01A183953, 4R00A178205-02, K25 EB016673, R01EB014944, R21 CA191679]
MSKCC Center for Molecular Imaging and Nanotechnology
Tow Foundation
MSKCC Experimental Therapeutics Center
National Science Foundation Integrative Graduate Education and Research Traineeship[IGERT 0965983]
Publisher
WileyJournal
ChemMedChemPubMed ID
27471800Additional Links
http://europepmc.org/articles/pmc5061038?pdf=renderae974a485f413a2113503eed53cd6c53
10.1002/cmdc.201600301
Scopus Count
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