Nickel-Catalyzed C sp2 –C sp3 Cross-Coupling via C–O Bond Activation
KAUST DepartmentKAUST Catalysis Center (KCC)
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AbstractA new and efficient nickel-catalyzed alkylation of CAr-O electrophiles with B-alkyl-9-BBNs is described. The transformation is characterized by its functional group tolerance and provides a practical and versatile access to various Csp2-Csp3 bonds through Csp2-O substitution, without the restriction of β-hydride elimination. Moreover, the advantage of the newly developed method was demonstrated in a selective and sequential C-O bond activation process. © 2016 American Chemical Society.
CitationGuo L, Hsiao C-C, Yue H, Liu X, Rueping M (2016) Nickel-Catalyzed C sp2 –C sp3 Cross-Coupling via C–O Bond Activation . ACS Catalysis 6: 4438–4442. Available: http://dx.doi.org/10.1021/acscatal.6b00801.
SponsorsL.G., H.Y., and X.L. gratefully acknowledge the China Scholarship Council. C.-C.H. gratefully acknowledges DAAD for fellowship.
PublisherAmerican Chemical Society (ACS)