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dc.contributor.authorCroissant, Jonas G.
dc.contributor.authorFatieiev, Yevhen
dc.contributor.authorOmar, Haneen
dc.contributor.authorAnjum, Dalaver H.
dc.contributor.authorGurinov, Andrei
dc.contributor.authorLu, Jie
dc.contributor.authorTamanoi, Fuyuhiko
dc.contributor.authorZink, Jeffrey I.
dc.contributor.authorKhashab, Niveen M.
dc.date.accessioned2016-11-03T13:22:30Z
dc.date.available2016-11-03T13:22:30Z
dc.date.issued2016-06-01
dc.identifier.citationCroissant JG, Fatieiev Y, Omar H, Anjum DH, Gurinov A, et al. (2016) Periodic Mesoporous Organosilica Nanoparticles with Controlled Morphologies and High Drug/Dye Loadings for Multicargo Delivery in Cancer Cells. Chem Eur J 22: 9607–9615. Available: http://dx.doi.org/10.1002/chem.201600587.
dc.identifier.issn0947-6539
dc.identifier.pmid27245497
dc.identifier.doi10.1002/chem.201600587
dc.identifier.urihttp://hdl.handle.net/10754/621675
dc.description.abstractDespite the worldwide interest generated by periodic mesoporous organosilica (PMO) bulk materials, the design of PMO nanomaterials with controlled morphology remains largely unexplored and their properties unknown. In this work, we describe the first study of PMO nanoparticles (NPs) based on meta-phenylene bridges, and we conducted a comparative structure–property relationship investigation with para-phenylene-bridged PMO NPs. Our findings indicate that the change of the isomer drastically affects the structure, morphology, size, porosity and thermal stability of PMO materials. We observed a much higher porosity and thermal stability of the para-based PMO which was likely due to a higher molecular periodicity. Additionally, the para isomer could generate multipodal NPs at very low stirring speed and upon this discovery we designed a phenylene–ethylene bridged PMO with a controlled Janus morphology. Unprecedentedly high payloads could be obtained from 40 to 110 wt % regardless of the organic bridge of PMOs. Finally, we demonstrate for the first time the co-delivery of two cargos by PMO NPs. Importantly, the cargo stability in PMOs did not require the capping of the pores, unlike pure silica, and the delivery could be autonomously triggered in cancer cells by acidic pH with nearly 70 % cell killing. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
dc.description.sponsorshipWe gratefully acknowledge support from King Abdullah University of Science and Technology (KAUST), and NSF Grant DBI-1266377.
dc.publisherWiley-Blackwell
dc.subjectBridged silsesquioxanes
dc.titlePeriodic Mesoporous Organosilica Nanoparticles with Controlled Morphologies and High Drug/Dye Loadings for Multicargo Delivery in Cancer Cells
dc.typeArticle
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentSmart Hybrid Materials (SHMs) lab
dc.contributor.departmentImaging and Characterization Core Lab
dc.identifier.journalChemistry - A European Journal
dc.contributor.institutionDepartment of Chemistry and Biochemistry; California NanoSystems Institute; Jonsson Comprehensive Cancer Center; University of California Los Angeles; Los Angeles California USA
dc.contributor.institutionDepartment of Microbiology; Immunology and Molecular Genetics; California NanoSystems Institute; Jonsson Comprehensive Cancer Center; University of California Los Angeles; Los Angeles California USA
kaust.personCroissant, Jonas G.
kaust.personFatieiev, Yevhen
kaust.personOmar, Haneen
kaust.personAnjum, Dalaver H.
kaust.personGurinov, Andrei
kaust.personKhashab, Niveen M.


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