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dc.contributor.authorSong, Xiaowan
dc.contributor.authorCao, Ming
dc.contributor.authorChen, Peng
dc.contributor.authorXia, Ru
dc.contributor.authorZheng, Zhengzhi
dc.contributor.authorMiao, Jibin
dc.contributor.authorYang, Bin
dc.contributor.authorSu, Lifen
dc.contributor.authorQian, Jiasheng
dc.contributor.authorFeng, Xiaoshuang
dc.date.accessioned2016-11-03T08:32:24Z
dc.date.available2016-11-03T08:32:24Z
dc.date.issued2016-05-28
dc.identifier.citationSong X, Cao M, Chen P, Xia R, Zheng Z, et al. (2016) Preparation of pH-sensitive amphiphilic block star polymers, their self-assembling characteristics and release behavior on encapsulated molecules. Polym Bull. Available: http://dx.doi.org/10.1007/s00289-016-1707-2.
dc.identifier.issn0170-0839
dc.identifier.issn1436-2449
dc.identifier.doi10.1007/s00289-016-1707-2
dc.identifier.urihttp://hdl.handle.net/10754/621572
dc.description.abstractPoly(ethylene glycol) (PEG), a polymer with excellent biocompatibility, was widely used to form nanoparticles for drug delivery applications. In this paper, based on PEG, a series of pH-sensitive amphiphilic block star polymers of poly(ethylene glycol)-block-poly(ethoxy ethyl glycidyl ether) (PEG-b-PEEGE) with different hydrophobic length were synthesized by living anionic ring-opening polymerization method. The products were characterized using 1H NMR and gel permeation chromatography. These copolymers could self-assemble in aqueous solution to form micellar structure with controlled morphologies. Transmission electron microscopy showed that the nanoparticles are spherical or rodlike with different hydrophilic mass fractions. The pH response of polymeric aggregates from PEG-b-PEEGE was detected by fluorescence probe technique at different pH. A pH-dependent release behavior was observed and pH-responsiveness of PEG-b-PEEGE was affected by the hydrophobic block length. These results demonstrated that star-shaped polymers (PEG-b-PEEGE) are attractive candidates as anticancer drug delivery carriers. © 2016 Springer-Verlag Berlin Heidelberg
dc.description.sponsorshipNational Natural Science Foundation of China[No.21174001]
dc.description.sponsorship"211 Project" of Anhui University[No. J01001319]
dc.publisherSpringer Nature
dc.subjectAnionic ring-opening polymerization (AROP)
dc.subjectBlock star polymer
dc.subjectpH-sensitive
dc.subjectSelf assembly
dc.titlePreparation of pH-sensitive amphiphilic block star polymers, their self-assembling characteristics and release behavior on encapsulated molecules
dc.typeArticle
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalPolymer Bulletin
dc.contributor.institutionKey Laboratory of Environment-Friendly Polymeric Materials of Anhui Province, School of Chemistry and Chemical Engineering, Anhui University, Hefei, China
kaust.personFeng, Xiaoshuang
dc.date.published-online2016-05-28
dc.date.published-print2017-01


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