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    Preparation of pH-sensitive amphiphilic block star polymers, their self-assembling characteristics and release behavior on encapsulated molecules

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    Type
    Article
    Authors
    Song, Xiaowan
    Cao, Ming
    Chen, Peng
    Xia, Ru
    Zheng, Zhengzhi
    Miao, Jibin
    Yang, Bin cc
    Su, Lifen
    Qian, Jiasheng
    Feng, Xiaoshuang
    KAUST Department
    Physical Science and Engineering (PSE) Division
    Date
    2016-05-28
    Online Publication Date
    2016-05-28
    Print Publication Date
    2017-01
    Permanent link to this record
    http://hdl.handle.net/10754/621572
    
    Metadata
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    Abstract
    Poly(ethylene glycol) (PEG), a polymer with excellent biocompatibility, was widely used to form nanoparticles for drug delivery applications. In this paper, based on PEG, a series of pH-sensitive amphiphilic block star polymers of poly(ethylene glycol)-block-poly(ethoxy ethyl glycidyl ether) (PEG-b-PEEGE) with different hydrophobic length were synthesized by living anionic ring-opening polymerization method. The products were characterized using 1H NMR and gel permeation chromatography. These copolymers could self-assemble in aqueous solution to form micellar structure with controlled morphologies. Transmission electron microscopy showed that the nanoparticles are spherical or rodlike with different hydrophilic mass fractions. The pH response of polymeric aggregates from PEG-b-PEEGE was detected by fluorescence probe technique at different pH. A pH-dependent release behavior was observed and pH-responsiveness of PEG-b-PEEGE was affected by the hydrophobic block length. These results demonstrated that star-shaped polymers (PEG-b-PEEGE) are attractive candidates as anticancer drug delivery carriers. © 2016 Springer-Verlag Berlin Heidelberg
    Citation
    Song X, Cao M, Chen P, Xia R, Zheng Z, et al. (2016) Preparation of pH-sensitive amphiphilic block star polymers, their self-assembling characteristics and release behavior on encapsulated molecules. Polym Bull. Available: http://dx.doi.org/10.1007/s00289-016-1707-2.
    Sponsors
    National Natural Science Foundation of China[No.21174001]
    "211 Project" of Anhui University[No. J01001319]
    Publisher
    Springer Nature
    Journal
    Polymer Bulletin
    DOI
    10.1007/s00289-016-1707-2
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00289-016-1707-2
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division

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