Preparation of pH-sensitive amphiphilic block star polymers, their self-assembling characteristics and release behavior on encapsulated molecules
Type
ArticleAuthors
Song, XiaowanCao, Ming
Chen, Peng
Xia, Ru
Zheng, Zhengzhi
Miao, Jibin
Yang, Bin

Su, Lifen
Qian, Jiasheng
Feng, Xiaoshuang
KAUST Department
Physical Science and Engineering (PSE) DivisionDate
2016-05-28Online Publication Date
2016-05-28Print Publication Date
2017-01Permanent link to this record
http://hdl.handle.net/10754/621572
Metadata
Show full item recordAbstract
Poly(ethylene glycol) (PEG), a polymer with excellent biocompatibility, was widely used to form nanoparticles for drug delivery applications. In this paper, based on PEG, a series of pH-sensitive amphiphilic block star polymers of poly(ethylene glycol)-block-poly(ethoxy ethyl glycidyl ether) (PEG-b-PEEGE) with different hydrophobic length were synthesized by living anionic ring-opening polymerization method. The products were characterized using 1H NMR and gel permeation chromatography. These copolymers could self-assemble in aqueous solution to form micellar structure with controlled morphologies. Transmission electron microscopy showed that the nanoparticles are spherical or rodlike with different hydrophilic mass fractions. The pH response of polymeric aggregates from PEG-b-PEEGE was detected by fluorescence probe technique at different pH. A pH-dependent release behavior was observed and pH-responsiveness of PEG-b-PEEGE was affected by the hydrophobic block length. These results demonstrated that star-shaped polymers (PEG-b-PEEGE) are attractive candidates as anticancer drug delivery carriers. © 2016 Springer-Verlag Berlin HeidelbergCitation
Song X, Cao M, Chen P, Xia R, Zheng Z, et al. (2016) Preparation of pH-sensitive amphiphilic block star polymers, their self-assembling characteristics and release behavior on encapsulated molecules. Polym Bull. Available: http://dx.doi.org/10.1007/s00289-016-1707-2.Sponsors
National Natural Science Foundation of China[No.21174001]"211 Project" of Anhui University[No. J01001319]
Publisher
Springer NatureJournal
Polymer Bulletinae974a485f413a2113503eed53cd6c53
10.1007/s00289-016-1707-2