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dc.contributor.authorBruggeman, Quentin
dc.contributor.authorMazubert, Christelle
dc.contributor.authorPrunier, Florence
dc.contributor.authorLugan, Raphael
dc.contributor.authorChan, Kai Xun
dc.contributor.authorPhua, Su Yin
dc.contributor.authorPogson, Barry J.
dc.contributor.authorKrieger-Liszkay, Anja
dc.contributor.authorDelarue, Marianne
dc.contributor.authorBenhamed, Moussa
dc.contributor.authorBergounioux, Catherine
dc.contributor.authorRaynaud, Cécile
dc.date.accessioned2016-11-03T08:30:04Z
dc.date.available2016-11-03T08:30:04Z
dc.date.issued2016-01-08
dc.identifier.citationBruggeman Q, Mazubert C, Prunier F, Lugan R, Chan KX, et al. (2016) Chloroplasts activity and PAP-signaling regulate programmed cell death in Arabidopsis. Plant Physiol: pp.01872.2015. Available: http://dx.doi.org/10.1104/pp.15.01872.
dc.identifier.issn0032-0889
dc.identifier.issn1532-2548
dc.identifier.pmid26747283
dc.identifier.doi10.1104/pp.15.01872
dc.identifier.urihttp://hdl.handle.net/10754/621468
dc.description.abstractProgrammed cell death (PCD) is a crucial process both for plant development and responses to biotic and abiotic stress. There is accumulating evidence that chloroplasts may play a central role during plant PCD as for mitochondria in animal cells, but it is still unclear whether they participate in PCD onset, execution, or both. To tackle this question, we have analyzed the contribution of chloroplast function to the cell death phenotype of the myoinositol phosphate synthase1 (mips1) mutant that forms spontaneous lesions in a light-dependent manner. We show that photosynthetically active chloroplasts are required for PCD to occur in mips1, but this process is independent of the redox state of the chloroplast. Systematic genetic analyses with retrograde signaling mutants reveal that 3’-phosphoadenosine 5’-phosphate, a chloroplast retrograde signal that modulates nuclear gene expression in response to stress, can inhibit cell death and compromises plant innate immunity via inhibition of the RNA-processing 5’-3’ exoribonucleases. Our results provide evidence for the role of chloroplast-derived signal and RNA metabolism in the control of cell death and biotic stress response. © 2016 American Society of Plant Biologists. All Rights Reserved.
dc.description.sponsorshipThis work was supported by the Agence Nationale de la Recherche (grant nos. ANR 2010 JCJC1207 01 and MAPK-IPS ANR-2010-BLAN-1613-02).
dc.publisherAmerican Society of Plant Biologists (ASPB)
dc.titleChloroplasts activity and PAP-signaling regulate programmed cell death in Arabidopsis
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentDesert Agriculture Initiative
dc.contributor.departmentPlant Science
dc.contributor.departmentPlant Science Program
dc.identifier.journalPlant Physiology
dc.contributor.institutionInstitute of Plant Sciences Paris-Saclay (IPS2), UMR 9213/UMR1403, CNRS, INRA, Université Paris-Sud, Université d’Evry, Université Paris-Diderot, Sorbonne Paris-Cité, Bâtiment 630, Orsay, France
dc.contributor.institutionCNRS UMR 7205, Muséum National d’Histoire Naturelle, CP50, 45 rue Buffon, Paris, France
dc.contributor.institutionInstitut de Biologie Moléculaire des Plantes, Unité Propre de Recherche 2357 CNRS, Université de Strasbourg, 12 rue du Général Zimmer, Strasbourg cedex, France
dc.contributor.institutionLaboratoire de Physiologie des Fruits et Légumes, Université d’Avignon et des Pays du Vaucluse, Bat. Agrosciences, Avignon cedex 9, France
dc.contributor.institutionAustralian Research Council Centre of Excellence in Plant Energy Biology, Research School of Biology, Australian National University, Acton, ACT, Australia
dc.contributor.institutionInstitute for Integrative Biology of the Cell (I2BC), Commissariat à l’Energie Atomique et aux Energies Alternatives Saclay, Centre National de la Recherche Scientifique, Université Paris-Sud, Gif-sur-Yvette cedex, France
kaust.personBenhamed, Moussa
dc.date.published-online2016-01-08
dc.date.published-print2016-03


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