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    Microfluidic device for continuous single cells analysis via Raman spectroscopy enhanced by integrated plasmonic nanodimers

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    Type
    Article
    Authors
    Perozziello, Gerardo
    Candeloro, Patrizio cc
    De Grazia, Antonio cc
    Esposito, Francesco
    Allione, Marco cc
    Coluccio, Maria Laura
    Tallerico, Rossana
    Valpapuram, Immanuel
    Tirinato, Luca cc
    Das, Gobind cc
    Giugni, Andrea
    Torre, Bruno
    Veltri, Pierangelo
    Kruhne, Ulrich
    Della Valle, Giuseppe
    Di Fabrizio, Enzo M. cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Material Science and Engineering Program
    Physical Science and Engineering (PSE) Division
    Date
    2015-12-11
    Online Publication Date
    2015-12-11
    Print Publication Date
    2016-01-25
    Permanent link to this record
    http://hdl.handle.net/10754/621445
    
    Metadata
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    Abstract
    In this work a Raman flow cytometer is presented. It consists of a microfluidic device that takes advantages of the basic principles of Raman spectroscopy and flow cytometry. The microfluidic device integrates calibrated microfluidic channels- where the cells can flow one-by-one -, allowing single cell Raman analysis. The microfluidic channel integrates plasmonic nanodimers in a fluidic trapping region. In this way it is possible to perform Enhanced Raman Spectroscopy on single cell. These allow a label-free analysis, providing information about the biochemical content of membrane and cytoplasm of the each cell. Experiments are performed on red blood cells (RBCs), peripheral blood lymphocytes (PBLs) and myelogenous leukemia tumor cells (K562). © 2015 Optical Society of America.
    Citation
    Perozziello G, Candeloro P, De Grazia A, Esposito F, Allione M, et al. (2015) Microfluidic device for continuous single cells analysis via Raman spectroscopy enhanced by integrated plasmonic nanodimers. Optics Express 24: A180. Available: http://dx.doi.org/10.1364/oe.24.00a180.
    Sponsors
    This work was partially supported by the European project EUROMBR (grant no. 608104), Cariplo Foundation under the project "New Frontiers in Plasmonic Nanosensing" (Grant no. 2011-0338), the project for Young researchers financed from the Ministry of Health "High Throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices" (CUP J65C13001350001, project no. GR-2010-2311677) granted to the nanotechnology laboratory of the Department of Experimental and Clinical Medicine of the University "Magna Graecia" of Catanzaro.
    Publisher
    The Optical Society
    Journal
    Optics Express
    DOI
    10.1364/oe.24.00a180
    ae974a485f413a2113503eed53cd6c53
    10.1364/oe.24.00a180
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Physical Science and Engineering (PSE) Division; Material Science and Engineering Program

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