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dc.contributor.authorBaud, Maxime O.
dc.contributor.authorParafita, Julia
dc.contributor.authorNguyen, Audrey
dc.contributor.authorMagistretti, Pierre J.
dc.contributor.authorPetit, Jean-Marie
dc.date.accessioned2016-11-03T08:29:24Z
dc.date.available2016-11-03T08:29:24Z
dc.date.issued2016-05-03
dc.identifier.citationBaud MO, Parafita J, Nguyen A, Magistretti PJ, Petit J-M (2016) Sleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposure. Journal of Sleep Research 25: 583–590. Available: http://dx.doi.org/10.1111/jsr.12419.
dc.identifier.issn0962-1105
dc.identifier.doi10.1111/jsr.12419
dc.identifier.urihttp://hdl.handle.net/10754/621441
dc.description.abstract© 2016 European Sleep Research Society. Sleep is viewed as a fundamental restorative function of the brain, but its specific role in neural energy budget remains poorly understood. Sleep deprivation dampens brain energy metabolism and impairs cognitive functions. Intriguingly, sleep fragmentation, despite normal total sleep duration, has a similar cognitive impact, and in this paper we ask the question of whether it may also impair brain energy metabolism. To this end, we used a recently developed mouse model of 2 weeks of sleep fragmentation and measured 2-deoxy-glucose uptake and glycogen, glucose and lactate concentration in different brain regions. In order to homogenize mice behaviour during metabolic measurements, we exposed them to a novel environment for 1 h. Using an intra-hippocampal electrode, we first showed that hippocampal electroencephalograph (EEG) response to exploration was unaltered by 1 or 14 days of sleep fragmentation. However, after 14 days, sleep fragmented mice exhibited a lower uptake of 2-deoxy-glucose in cortex and hippocampus and lower cortical lactate levels than control mice. Our results suggest that long-term sleep fragmentation impaired brain metabolism to a similar extent as total sleep deprivation without affecting the neuronal responsiveness of hippocampus to a novel environment.
dc.description.sponsorshipSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung[323600-119351/1, 3100AO-108336/1]
dc.publisherWiley
dc.subjectAstrocyte-neurone lactate shuttle
dc.subjectBeta rhythm
dc.subjectEnergy metabolism
dc.subjectExploratory behavior
dc.subjectNeurometabolic coupling
dc.titleSleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposure
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalJournal of Sleep Research
dc.contributor.institutionLNDC; Brain Mind Institute; Faculté des Sciences de la Vie; Ecole Polytechnique Fédérale de Lausanne (EPFL); Lausanne Switzerland
dc.contributor.institutionDepartment of Neurology; UCSF; San Francisco CA USA
dc.contributor.institutionCentre de Neurosciences Psychiatriques; Centre Hospitalier Universitaire Vaudois (CHUV); Prilly Switzerland
kaust.personMagistretti, Pierre J.
dc.date.published-online2016-05-03
dc.date.published-print2016-10


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