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    Sleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposure

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    Type
    Article
    Authors
    Baud, Maxime O.
    Parafita, Julia
    Nguyen, Audrey
    Magistretti, Pierre J. cc
    Petit, Jean-Marie
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Date
    2016-05-03
    Online Publication Date
    2016-05-03
    Print Publication Date
    2016-10
    Permanent link to this record
    http://hdl.handle.net/10754/621441
    
    Metadata
    Show full item record
    Abstract
    © 2016 European Sleep Research Society. Sleep is viewed as a fundamental restorative function of the brain, but its specific role in neural energy budget remains poorly understood. Sleep deprivation dampens brain energy metabolism and impairs cognitive functions. Intriguingly, sleep fragmentation, despite normal total sleep duration, has a similar cognitive impact, and in this paper we ask the question of whether it may also impair brain energy metabolism. To this end, we used a recently developed mouse model of 2 weeks of sleep fragmentation and measured 2-deoxy-glucose uptake and glycogen, glucose and lactate concentration in different brain regions. In order to homogenize mice behaviour during metabolic measurements, we exposed them to a novel environment for 1 h. Using an intra-hippocampal electrode, we first showed that hippocampal electroencephalograph (EEG) response to exploration was unaltered by 1 or 14 days of sleep fragmentation. However, after 14 days, sleep fragmented mice exhibited a lower uptake of 2-deoxy-glucose in cortex and hippocampus and lower cortical lactate levels than control mice. Our results suggest that long-term sleep fragmentation impaired brain metabolism to a similar extent as total sleep deprivation without affecting the neuronal responsiveness of hippocampus to a novel environment.
    Citation
    Baud MO, Parafita J, Nguyen A, Magistretti PJ, Petit J-M (2016) Sleep fragmentation alters brain energy metabolism without modifying hippocampal electrophysiological response to novelty exposure. Journal of Sleep Research 25: 583–590. Available: http://dx.doi.org/10.1111/jsr.12419.
    Sponsors
    Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung[323600-119351/1, 3100AO-108336/1]
    Publisher
    Wiley
    Journal
    Journal of Sleep Research
    DOI
    10.1111/jsr.12419
    ae974a485f413a2113503eed53cd6c53
    10.1111/jsr.12419
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program

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