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    Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation

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    Type
    Article
    Authors
    Gao, Virginia
    Suzuki, Akinobu
    Magistretti, Pierre J. cc
    Lengacher, Sylvain
    Pollonini, Gabriella
    Steinman, Michael Q.
    Alberini, Cristina M.
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Date
    2016-07-08
    Online Publication Date
    2016-07-08
    Print Publication Date
    2016-07-26
    Permanent link to this record
    http://hdl.handle.net/10754/621430
    
    Metadata
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    Abstract
    Emotionally relevant experiences form strong and long-lasting memories by critically engaging the stress hormone/neurotransmitter noradrenaline, which mediates and modulates the consolidation of these memories. Noradrenaline acts through adrenergic receptors (ARs), of which β2- Adrenergic receptors (βARs) are of particular importance. The differential anatomical and cellular distribution of βAR subtypes in the brain suggests that they play distinct roles in memory processing, although much about their specific contributions and mechanisms of action remains to be understood. Here we show that astrocytic rather than neuronal β2ARs in the hippocampus play a key role in the consolidation of a fear-based contextual memory. These hippocampal β2ARs, but not β1ARs, are coupled to the training-dependent release of lactate from astrocytes, which is necessary for long- Term memory formation and for underlying molecular changes. This key metabolic role of astrocytic β2ARs may represent a novel target mechanism for stress-related psychopathologies and neurodegeneration.
    Citation
    Gao V, Suzuki A, Magistretti PJ, Lengacher S, Pollonini G, et al. (2016) Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation. Proc Natl Acad Sci USA 113: 8526–8531. Available: http://dx.doi.org/10.1073/pnas.1605063113.
    Sponsors
    We thank Dr. Karl Deisseroth (Stanford University) for generously providing pAAV-hSyn plasmids; Dr. Mark Kay (Stanford University) for generously providing the pRC-DJ plasmid used to produce AAVDJ; Dr. Bernard Schneider (Ecole Polytechnic Federale de Lausanne) for generously providing the pAAV-short gfaABC1D-eGFP plasmid used to produce AAV9; and Dr. Alberto Julio Kaumann (University of Murcia) for helpful advice concerning beta AR radiolabeling. This work was supported by NIH Grant R01 MH100822 and the McKnight Memory and Cognitive Disorder Award (to C.M.A.) and NIH Grant F30 MH098570 (to V.G.).
    Publisher
    Proceedings of the National Academy of Sciences
    Journal
    Proceedings of the National Academy of Sciences
    DOI
    10.1073/pnas.1605063113
    PubMed ID
    27402767
    ae974a485f413a2113503eed53cd6c53
    10.1073/pnas.1605063113
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program

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