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dc.contributor.authorChatton, Jean-Yves
dc.contributor.authorMagistretti, Pierre J.
dc.contributor.authorBarros, L. Felipe
dc.date.accessioned2016-11-03T08:28:47Z
dc.date.available2016-11-03T08:28:47Z
dc.date.issued2016-03-31
dc.identifier.citationChatton J-Y, Magistretti PJ, Barros LF (2016) Sodium signaling and astrocyte energy metabolism. Glia 64: 1667–1676. Available: http://dx.doi.org/10.1002/glia.22971.
dc.identifier.issn0894-1491
dc.identifier.doi10.1002/glia.22971
dc.identifier.urihttp://hdl.handle.net/10754/621415
dc.description.abstractThe Na+ gradient across the plasma membrane is constantly exploited by astrocytes as a secondary energy source to regulate the intracellular and extracellular milieu, and discard waste products. One of the most prominent roles of astrocytes in the brain is the Na+-dependent clearance of glutamate released by neurons during synaptic transmission. The intracellular Na+ load collectively generated by these processes converges at the Na,K-ATPase pump, responsible for Na+ extrusion from the cell, which is achieved at the expense of cellular ATP. These processes represent pivotal mechanisms enabling astrocytes to increase the local availability of metabolic substrates in response to neuronal activity. This review presents basic principles linking the intracellular handling of Na+ following activity-related transmembrane fluxes in astrocytes and the energy metabolic pathways involved. We propose a role of Na+ as an energy currency and as a mediator of metabolic signals in the context of neuron-glia interactions. We further discuss the possible impact of the astrocytic syncytium for the distribution and coordination of the metabolic response, and the compartmentation of these processes in cellular microdomains and subcellular organelles. Finally, we illustrate future avenues of investigation into signaling mechanisms aimed at bridging the gap between Na+ and the metabolic machinery. © 2016 Wiley Periodicals, Inc.
dc.description.sponsorshipComisión Nacional de Investigación Científica y Tecnológica
dc.description.sponsorshipFondecyt[1130095]
dc.publisherWiley
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/glia.22971/full
dc.relation.urlhttps://serval.unil.ch/resource/serval:BIB_D88ECDA61995.P002/REF.pdf
dc.rightsArchived with thanks to Wiley
dc.subjectGlycolysis
dc.subjectLactate
dc.subjectMembrane transport
dc.subjectMitochondria
dc.subjectNa,K-ATPase
dc.subjectNeuron-glia interactions
dc.subjectSyncytium
dc.titleSodium signaling and astrocyte energy metabolism
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalGlia
dc.rights.embargodate2017-03-31
dc.eprint.versionPost-print
dc.contributor.institutionDepartment of Fundamental Neurosciences; University of Lausanne; Rue Du Bugnon 9 Lausanne Switzerland
dc.contributor.institutionBrain Mind Institute, Ecole Polytechnique Fédérale De Lausanne (EPFL); Lausanne Switzerland
dc.contributor.institutionCentro De Estudios Científicos; Valdivia Chile
kaust.personMagistretti, Pierre J.
refterms.dateFOA2020-03-30T09:18:35Z
dc.date.published-online2016-03-29
dc.date.published-print2016-10


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