Sensors and Instrumentation towards early detection of osteoporosis

Abstract
A label-free non-invasive sensing system for detection of C-terminal telopeptide of type-I collagen (CTX-I) has been developed in order to detect bone loss at an early stage, by Electrochemical Impedance Spectroscopy (EIS). A planar interdigital sensor was functionalized by immobilizing streptavidin agarose on the sensing area of the sensor to introduce selectivity for the antigen-antibody solution. Different concentrations of CTX-I were tested using the functionalized sensing surface to capture the target molecule. Preliminary results are provided in the paper assisted with the respective equivalent circuit of the working technology on the sensor using Complex Non-linear Least Square (CNLS). The results are encouraging and will be used to develop a complete system for commercialization complementing the existing systems. © 2016 IEEE.

Citation
Afsarimanesh N, Mukhopadhyay SC, Kruger M, Yu P-L, Kosel J (2016) Sensors and Instrumentation towards early detection of osteoporosis. 2016 IEEE International Instrumentation and Measurement Technology Conference Proceedings. Available: http://dx.doi.org/10.1109/I2MTC.2016.7520573.

Publisher
Institute of Electrical and Electronics Engineers (IEEE)

Journal
2016 IEEE International Instrumentation and Measurement Technology Conference Proceedings

Conference/Event Name
2016 IEEE International Instrumentation and Measurement Technology Conference, I2MTC 2016

DOI
10.1109/I2MTC.2016.7520573

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