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dc.contributor.authorSivashankar, Shilpa
dc.contributor.authorAgambayev, Sumeyra
dc.contributor.authorAlamoudi, Kholod
dc.contributor.authorButtner, Ulrich
dc.contributor.authorKhashab, Niveen M.
dc.contributor.authorSalama, Khaled N.
dc.date.accessioned2016-11-03T07:43:53Z
dc.date.available2016-11-03T07:43:53Z
dc.date.issued2016-08-30
dc.identifier.citationSivashankar S, Agambayev S, Alamoudi K, Buttner U, Khashab N, et al. (2016) Compatibility analysis of 3D printer resin for biological applications . Micro & Nano Letters 11: 654–659. Available: http://dx.doi.org/10.1049/mnl.2016.0530.
dc.identifier.issn1750-0443
dc.identifier.doi10.1049/mnl.2016.0530
dc.identifier.urihttp://hdl.handle.net/10754/621269
dc.description.abstractThe salient features of microfluidics such as reduced cost, handling small sample and reagent volumes and less time required to fabricate the devices has inspired the present work. The incompatibility of three-dimensional printer resins in their native form and the method to improve their compatibility to many biological processes via surface modification are reported. The compatibility of the material to build microfluidic devices was evaluated in three different ways: (i) determining if the ultraviolet (UV) cured resin inhibits the polymerase chain reaction (PCR), i.e. testing devices for PCR compatibility; (ii) observing agglutination complex formed on the surface of the UV cured resin when anti-C-reactive protein (CRP) antibodies and CRP proteins were allowed to agglutinate; and (iii) by culturing human embryonic kidney cell line cells and testing for its attachment and viability. It is shown that only a few among four in its native form could be used for fabrication of microchannels and that had the least effect on biological molecules that could be used for PCR and protein interactions and cells, whereas the others were used after treating the surface. Importance in building lab-on-chip/micrototal analysis systems and organ-on-chip devices is found.
dc.publisherInstitution of Engineering and Technology (IET)
dc.relation.urlhttp://ieeexplore.ieee.org/document/7660890/
dc.rightsThis is an open access article published by the IET under the Creative Commons Attribution-NonCommercial-NoDerivs License
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectbiological techniques
dc.subjectresins
dc.subjectmicrofluidics
dc.subjectbioMEMS
dc.subjectmicrofabrication
dc.subjectsurface treatment
dc.subjectcuring
dc.subjectenzymes
dc.subjectmolecular biophysics
dc.subjectbiochemistry
dc.subjectkidney
dc.subjectcellular biophysics
dc.subjectorgan-on-chip devices
dc.subjectcompatibility analysis
dc.subjectthree-dimensional printer resins
dc.subjectmicrofluidic devices
dc.subjectultraviolet cured resin
dc.subjectpolymerase chain reaction
dc.subjectPCR compatibility
dc.subjectagglutination complex
dc.subjectUV cured resin
dc.subjectantiC-reactive protein antibodies
dc.subjectCRP proteins
dc.subjecthuman embryonic kidney cell line
dc.subjectmicrochannel fabrication
dc.subjectprotein interactions
dc.subjectlab-on-chip-micrototal analysis
dc.titleCompatibility analysis of 3D printer resin for biological applications
dc.typeArticle
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentChemical Science Program
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentElectrical Engineering Program
dc.contributor.departmentNanofabrication Core Lab
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Division
dc.identifier.journalMicro & Nano Letters
dc.eprint.versionAccepted manuscript
kaust.personSivashankar, Shilpa
kaust.personAgambayev, Sumeyra
kaust.personAlamoudi, Kholod
kaust.personButtner, Ulrich
kaust.personKhashab, Niveen M.
kaust.personSalama, Khaled N.
refterms.dateFOA2018-06-13T14:36:34Z


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This is an open access article published by the IET under the Creative Commons Attribution-NonCommercial-NoDerivs License
Except where otherwise noted, this item's license is described as This is an open access article published by the IET under the Creative Commons Attribution-NonCommercial-NoDerivs License