Compatibility analysis of 3D printer resin for biological applications
Khashab, Niveen M.
Salama, Khaled N.
KAUST DepartmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Biological and Environmental Sciences and Engineering (BESE) Division
Advanced Nanofabrication and Thin Film Core Lab
Physical Sciences and Engineering (PSE) Division
Chemical Science Program
Electrical Engineering Program
Permanent link to this recordhttp://hdl.handle.net/10754/621269
MetadataShow full item record
AbstractThe salient features of microfluidics such as reduced cost, handling small sample and reagent volumes and less time required to fabricate the devices has inspired the present work. The incompatibility of three-dimensional printer resins in their native form and the method to improve their compatibility to many biological processes via surface modification are reported. The compatibility of the material to build microfluidic devices was evaluated in three different ways: (i) determining if the ultraviolet (UV) cured resin inhibits the polymerase chain reaction (PCR), i.e. testing devices for PCR compatibility; (ii) observing agglutination complex formed on the surface of the UV cured resin when anti-C-reactive protein (CRP) antibodies and CRP proteins were allowed to agglutinate; and (iii) by culturing human embryonic kidney cell line cells and testing for its attachment and viability. It is shown that only a few among four in its native form could be used for fabrication of microchannels and that had the least effect on biological molecules that could be used for PCR and protein interactions and cells, whereas the others were used after treating the surface. Importance in building lab-on-chip/micrototal analysis systems and organ-on-chip devices is found.
CitationSivashankar S, Agambayev S, Alamoudi K, Buttner U, Khashab N, et al. (2016) Compatibility analysis of 3D printer resin for biological applications . Micro & Nano Letters 11: 654–659. Available: http://dx.doi.org/10.1049/mnl.2016.0530.
JournalMicro & Nano Letters
CollectionsArticles; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Advanced Nanofabrication, Imaging and Characterization Core Lab; Physical Sciences and Engineering (PSE) Division; Electrical Engineering Program; Chemical Science Program; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Except where otherwise noted, this item's license is described as This is an open access article published by the IET under the Creative Commons Attribution-NonCommercial-NoDerivs License
Showing items related by title, author, creator and subject.
Ultrafiltration Membrane Fouling and the Effect of Ion Exchange ResinsJamaly, Sanaa (2011-12) [Thesis]
Advisor: Croue, Jean-Philippe
Committee members: Amy, Gary L.; Zhang, TaoMembrane fouling is a challenging process for the ultrafiltration membrane during wastewater treatment. This research paper determines the organic character of foulants of different kinds of wastewater before and after adding some ion exchange resins. Two advanced organic characterization methods are compared in terms of concentration of dissolved organic carbons: The liquid chromatography with organic carbon (LC-OCD) and Shimadzu total organic carbon (TOC). In this study, two secondary wastewater effluents were treated using ultrafiltration membrane. To reduce fouling, pretreatment using some adsorbents were used in the study. Six ion exchange resins out of twenty were chosen to compare the effect of adsorbents on fouling membrane. Based on the percent of dissolved organic carbon’s removal, three adsorbents were determined to be the most efficient (DOWEX Marathon 11 anion exchange resin, DOWEX Optipore SD2 polymeric adsorbent, and DOWEX PSR2 anion exchange), and three other ones were determined to the least efficient (DOWEX Marathon A2 anion exchange resin, DOWEX SAR anion exchange resin, and DOWEX Optipore L493 polymeric adsorbent). Organic characterization for feed, permeate, and backwash samples were tested using LC-OCD and TOC to better understand the characteristics of foulants to prevent ultrafiltration membrane fouling. The results suggested that the polymeric ion exchange resin, DOWEX SD2, reduced fouling potential for both treated wastewaters. All the six ion exchange resins removed more humic fraction than other organic fractions in different percent, so this fraction is not the main for cause for UF membrane fouling. The fouling of colloids was tested before and after adding calcium. There is a severe fouling after adding Ca2+ to effluent colloids.
Characterization of fracture toughness of epoxy resin after hygrothermal agingQuispe, Gustavo Q. (2013-07) [Thesis]
Advisor: Lubineau, Gilles
Committee members: Bourchak, Mostefa; Younis, Mohammad I.Characterization of fracture toughness of epoxy resin after hygrothermal ageing Gustavo Quino Quispe The aim of this work is to characterize the e ects of hygrothermal aging in the plain strain fracture toughness of the epoxy system composed by cycloaliphatic epoxy resin and diglycidyl ether of bisphenol-A (DGEBA). For this, after having been under hygrothermal aging in a climatic chamber, epoxy samples were studied using ASTM D5045 fracture toughness test, and micrography and roughness measurements of the fracture surface. It is reported a rapid decrease of GIc and KIc during the rst 2 days. Moreover, a numerical model  was used to simulate and see with more detail the water absorption in the aged samples. From that, it was observed the heterogeneous distribution of water. Accordingly, it was proposed that the results should be correlated with the water content at the vicinity of the crack tip. Consequently, it was possible to obtain, by quasi-static simulations, the ideal load-displacement curves of crack propagation in the heterogeneous samples. Finally, another contribution of this work is the study of the fracture surface, that gives a clue of the relationship among the fracture energy, the appearance of microcracks in the fracture surface, and the roughness (Ra).
Inkjet-Printed Wideband Antenna on Resin-Coated Paper Substrate for Curved Wireless DevicesAbutarboush, Hattan; Farooqui, Muhammad Fahad; Shamim, Atif (IEEE Antennas and Wireless Propagation Letters, Institute of Electrical and Electronics Engineers (IEEE), 2015-04-28) [Article]A low-cost, inkjet-printed multiband monopole antenna for conformal wireless applications is presented for the first time. The antenna is implemented on a low cost resin coated paper substrate which can be used for conformal devices. The antenna developed here is composed of four branch lines on the radiator and three L-shaped slots on the ground plane that help to generate multiple bands without increasing the size of the antenna. The antenna has a compact size, making it suitable for handheld and wearable wireless devices. Details of the inkjet printing fabrication processes and related issues are presented. The antennas were characterized under flat and bent conditions and the results indicate that the antennas can cover most bands for mobile and wireless applications such as PCS, UMTS, GSM1900 and WLAN