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dc.contributor.authorCarrard, A
dc.contributor.authorElsayed, M
dc.contributor.authorMargineanu, Michael B.
dc.contributor.authorBoury-Jamot, B
dc.contributor.authorFragnière, L
dc.contributor.authorMeylan, E M
dc.contributor.authorPetit, J-M
dc.contributor.authorFiumelli, Hubert
dc.contributor.authorMagistretti, Pierre J.
dc.contributor.authorMartin, J-L
dc.date.accessioned2016-10-20T11:44:43Z
dc.date.available2016-10-20T11:44:43Z
dc.date.issued2016-10-18
dc.identifier.citationCarrard A, Elsayed M, Margineanu M, Boury-Jamot B, Fragnière L, et al. (2016) Peripheral administration of lactate produces antidepressant-like effects. Molecular Psychiatry. Available: http://dx.doi.org/10.1038/mp.2016.179.
dc.identifier.issn1359-4184
dc.identifier.issn1476-5578
dc.identifier.doi10.1038/mp.2016.179
dc.identifier.urihttp://hdl.handle.net/10754/621086
dc.description.abstractIn addition to its role as metabolic substrate that can sustain neuronal function and viability, emerging evidence supports a role for l-lactate as an intercellular signaling molecule involved in synaptic plasticity. Clinical and basic research studies have shown that major depression and chronic stress are associated with alterations in structural and functional plasticity. These findings led us to investigate the role of l-lactate as a potential novel antidepressant. Here we show that peripheral administration of l-lactate produces antidepressant-like effects in different animal models of depression that respond to acute and chronic antidepressant treatment. The antidepressant-like effects of l-lactate are associated with increases in hippocampal lactate levels and with changes in the expression of target genes involved in serotonin receptor trafficking, astrocyte functions, neurogenesis, nitric oxide synthesis and cAMP signaling. Further elucidation of the mechanisms underlying the antidepressant effects of l-lactate may help to identify novel therapeutic targets for the treatment of depression.
dc.description.sponsorshipWe thank Dr I Allaman for critical reading of the manuscript and C Martin for assistance with preliminary experiments. This work was supported by the National Center of Competence in Research (NCCR) Synapsy, the Préfargier Foundation and by funding from King Abdullah University of Science and Technology (KAUST).
dc.publisherSpringer Nature
dc.relation.urlhttp://www.nature.com/mp/journal/vaop/ncurrent/full/mp2016179a.html
dc.rights© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titlePeripheral administration of lactate produces antidepressant-like effects
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalMolecular Psychiatry
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionCenter for Psychiatric Neurosciences, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland
dc.contributor.institutionBrain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
kaust.personMargineanu, Michael B.
kaust.personFiumelli, Hubert
kaust.personMagistretti, Pierre J.
refterms.dateFOA2018-06-13T12:56:00Z


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© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.
Except where otherwise noted, this item's license is described as © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.