Show simple item record

dc.contributor.authorKreuz, Sarah
dc.contributor.authorFischle, Wolfgang
dc.date.accessioned2016-07-26T09:29:53Z
dc.date.available2016-07-26T09:29:53Z
dc.date.issued2016-06-20
dc.identifier.citationOxidative stress signaling to chromatin in health and disease 2016, 8 (6):843 Epigenomics
dc.identifier.issn1750-1911
dc.identifier.issn1750-192X
dc.identifier.pmid27319358
dc.identifier.doi10.2217/epi-2016-0002
dc.identifier.urihttp://hdl.handle.net/10754/617554
dc.description.abstractOxidative stress has a significant impact on the development and progression of common human pathologies, including cancer, diabetes, hypertension and neurodegenerative diseases. Increasing evidence suggests that oxidative stress globally influences chromatin structure, DNA methylation, enzymatic and non-enzymatic post-translational modifications of histones and DNA-binding proteins. The effects of oxidative stress on these chromatin alterations mediate a number of cellular changes, including modulation of gene expression, cell death, cell survival and mutagenesis, which are disease-driving mechanisms in human pathologies. Targeting oxidative stress-dependent pathways is thus a promising strategy for the prevention and treatment of these diseases. We summarize recent research developments connecting oxidative stress and chromatin regulation.
dc.description.sponsorshipThe research reported in this publication was supported by funding from King Abdullah University of Science and Technology (KAUST). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
dc.language.isoen
dc.publisherFuture Medicine Ltd
dc.relation.urlhttp://www.futuremedicine.com/doi/10.2217/epi-2016-0002
dc.rightsThis work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleOxidative stress signaling to chromatin in health and disease
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentKAUST Environmental Epigenetics Research Program (KEEP)
dc.identifier.journalEpigenomics
dc.eprint.versionPublisher's Version/PDF
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personKreuz, Sarah
kaust.personFischle, Wolfgang
refterms.dateFOA2018-06-13T13:14:46Z
dc.date.published-online2016-06-20
dc.date.published-print2016-06


Files in this item

Thumbnail
Name:
epi-2016-0002.pdf
Size:
1.570Mb
Format:
PDF
Description:
Main article

This item appears in the following Collection(s)

Show simple item record