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    Oxidative stress signaling to chromatin in health and disease

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    epi-2016-0002.pdf
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    Type
    Article
    Authors
    Kreuz, Sarah
    Fischle, Wolfgang cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    KAUST Environmental Epigenetics Research Program (KEEP)
    Date
    2016-06-20
    Online Publication Date
    2016-06-20
    Print Publication Date
    2016-06
    Permanent link to this record
    http://hdl.handle.net/10754/617554
    
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    Abstract
    Oxidative stress has a significant impact on the development and progression of common human pathologies, including cancer, diabetes, hypertension and neurodegenerative diseases. Increasing evidence suggests that oxidative stress globally influences chromatin structure, DNA methylation, enzymatic and non-enzymatic post-translational modifications of histones and DNA-binding proteins. The effects of oxidative stress on these chromatin alterations mediate a number of cellular changes, including modulation of gene expression, cell death, cell survival and mutagenesis, which are disease-driving mechanisms in human pathologies. Targeting oxidative stress-dependent pathways is thus a promising strategy for the prevention and treatment of these diseases. We summarize recent research developments connecting oxidative stress and chromatin regulation.
    Citation
    Oxidative stress signaling to chromatin in health and disease 2016, 8 (6):843 Epigenomics
    Sponsors
    The research reported in this publication was supported by funding from King Abdullah University of Science and Technology (KAUST). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
    Publisher
    Future Medicine Ltd
    Journal
    Epigenomics
    DOI
    10.2217/epi-2016-0002
    PubMed ID
    27319358
    Additional Links
    http://www.futuremedicine.com/doi/10.2217/epi-2016-0002
    ae974a485f413a2113503eed53cd6c53
    10.2217/epi-2016-0002
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program

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