Type
ArticleAuthors
Kreuz, SarahFischle, Wolfgang

KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
KAUST Environmental Epigenetics Research Program (KEEP)
Date
2016-06-20Online Publication Date
2016-06-20Print Publication Date
2016-06Permanent link to this record
http://hdl.handle.net/10754/617554
Metadata
Show full item recordAbstract
Oxidative stress has a significant impact on the development and progression of common human pathologies, including cancer, diabetes, hypertension and neurodegenerative diseases. Increasing evidence suggests that oxidative stress globally influences chromatin structure, DNA methylation, enzymatic and non-enzymatic post-translational modifications of histones and DNA-binding proteins. The effects of oxidative stress on these chromatin alterations mediate a number of cellular changes, including modulation of gene expression, cell death, cell survival and mutagenesis, which are disease-driving mechanisms in human pathologies. Targeting oxidative stress-dependent pathways is thus a promising strategy for the prevention and treatment of these diseases. We summarize recent research developments connecting oxidative stress and chromatin regulation.Citation
Oxidative stress signaling to chromatin in health and disease 2016, 8 (6):843 EpigenomicsSponsors
The research reported in this publication was supported by funding from King Abdullah University of Science and Technology (KAUST). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.Publisher
Future Medicine LtdJournal
EpigenomicsPubMed ID
27319358Additional Links
http://www.futuremedicine.com/doi/10.2217/epi-2016-0002ae974a485f413a2113503eed53cd6c53
10.2217/epi-2016-0002
Scopus Count
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