Tin-free visible light photoredox catalysed cyclisation of enamides as a mild procedure for the synthesis of γ-lactams
KAUST DepartmentKAUST Catalysis Center (KCC)
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AbstractThe first visible light mediated tin-free cyclisation of α-chloroenamides leading to the synthesis of substituted γ-lactams with excellent stereoselectivity is reported. The protocol employs the single-electron reduction of activated C–Cl bonds, which are typically inert towards reduction.
CitationTin-free visible light photoredox catalysed cyclisation of enamides as a mild procedure for the synthesis of γ-lactams 2016 Green Chem.
SponsorsThe research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement No. 617044 (SunCatChem). Financial support by KAUST is gratefully acknowledged.
PublisherRoyal Society of Chemistry (RSC)