Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible Light Triggered Platform for facile siRNA Delivery
Type
ArticleAuthors
Patil, Sachin
Moosa, Basem
Alsaiari, Shahad
Alamoudi, Kholod
Alshamsan, Aws
Almailk, Abdulaziz
Adil, Karim
Eddaoudi, Mohamed
Khashab, Niveen M.
KAUST Department
Advanced Membranes and Porous Materials Research CenterChemical Science Program
Functional Materials Design, Discovery and Development (FMD3)
Physical Science and Engineering (PSE) Division
Smart Hybrid Materials (SHMs) lab
Date
2016-07-28Online Publication Date
2016-07-28Print Publication Date
2016-09-19Permanent link to this record
http://hdl.handle.net/10754/615926Metadata
Show full item recordAbstract
Supramolecular self-assembly of histidine-capped-dialkoxy-anthracene (HDA) results in the formation of light responsive nanostructures.Single-crystal X-ray diffraction analysis of HDA shows two types of hydrogen bonding. The first hydrogen bond is established between the imidazole moieties while the second involves the oxygen atom of one amide group and the hydrogen atom of a second amide group. When protonated in acidic aqueous media, HDA successfully complexes siRNA yielding spherical nanostructures. This biocompatible platform controllably delivers siRNA with high efficacy upon visible light irradiation leading up to 90% of gene silencing in live cells.Citation
Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible Light Triggered Platform for facile siRNA Delivery 2016 Chemistry - A European JournalPublisher
WileyJournal
Chemistry - A European JournalPubMed ID
27356263Additional Links
http://doi.wiley.com/10.1002/chem.201601442Relations
Is Supplemented By:- [Dataset]
Patil, S. P., Moosa, B. A., Alsaiari, S., Alamoudi, K., Alshamsan, A., AlMalik, A., … Khashab, N. M. (2016). CCDC 1442746: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccdc.csd.cc1kf96h. DOI: 10.5517/ccdc.csd.cc1kf96h HANDLE: 10754/624553