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    Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible Light Triggered Platform for facile siRNA Delivery

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    Patil_et_al-2016-Chemistry_-_A_European_Journal.pdf
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    Description:
    Accepted Manuscript
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    Type
    Article
    Authors
    Patil, Sachin cc
    Moosa, Basem cc
    Alsaiari, Shahad
    Alamoudi, Kholod cc
    Alshamsan, Aws
    Almailk, Abdulaziz
    Adil, Karim cc
    Eddaoudi, Mohamed cc
    Khashab, Niveen M. cc
    KAUST Department
    Advanced Membranes and Porous Materials Research Center
    Chemical Science Program
    Functional Materials Design, Discovery and Development (FMD3)
    Physical Science and Engineering (PSE) Division
    Smart Hybrid Materials (SHMs) lab
    Date
    2016-07-28
    Online Publication Date
    2016-07-28
    Print Publication Date
    2016-09-19
    Permanent link to this record
    http://hdl.handle.net/10754/615926
    
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    Abstract
    Supramolecular self-assembly of histidine-capped-dialkoxy-anthracene (HDA) results in the formation of light responsive nanostructures.Single-crystal X-ray diffraction analysis of HDA shows two types of hydrogen bonding. The first hydrogen bond is established between the imidazole moieties while the second involves the oxygen atom of one amide group and the hydrogen atom of a second amide group. When protonated in acidic aqueous media, HDA successfully complexes siRNA yielding spherical nanostructures. This biocompatible platform controllably delivers siRNA with high efficacy upon visible light irradiation leading up to 90% of gene silencing in live cells.
    Citation
    Supramolecular Self-Assembly of Histidine-Capped-Dialkoxy-Anthracene: A Visible Light Triggered Platform for facile siRNA Delivery 2016 Chemistry - A European Journal
    Publisher
    Wiley
    Journal
    Chemistry - A European Journal
    DOI
    10.1002/chem.201601442
    PubMed ID
    27356263
    Additional Links
    http://doi.wiley.com/10.1002/chem.201601442
    Relations
    Is Supplemented By:
    • [Dataset]
      Patil, S. P., Moosa, B. A., Alsaiari, S., Alamoudi, K., Alshamsan, A., AlMalik, A., … Khashab, N. M. (2016). CCDC 1442746: Experimental Crystal Structure Determination [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/ccdc.csd.cc1kf96h. DOI: 10.5517/ccdc.csd.cc1kf96h HANDLE: 10754/624553
    ae974a485f413a2113503eed53cd6c53
    10.1002/chem.201601442
    Scopus Count
    Collections
    Articles; Advanced Membranes and Porous Materials Research Center; Physical Science and Engineering (PSE) Division; Chemical Science Program

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