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    Tumor-derived circulating endothelial cell clusters in colorectal cancer.

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    Type
    Article
    Authors
    Cima, Igor
    Kong, Say Li
    Sengupta, Debarka
    Tan, Iain B
    Phyo, Wai Min
    Lee, Daniel
    Hu, Min
    Iliescu, Ciprian
    Alexander, Irina
    Goh, Wei Lin
    Rahmani, Mehran
    Suhaimi, Nur-Afidah Mohamed
    Vo, Jess H
    Tai, Joyce A
    Tan, Joanna H
    Chua, Clarinda
    Ten, Rachel
    Lim, Wan Jun
    Chew, Min Hoe
    Hauser, Charlotte cc
    van Dam, Rob M
    Lim, Wei-Yen
    Prabhakar, Shyam
    Lim, Bing
    Koh, Poh Koon
    Robson, Paul
    Ying, Jackie Y
    Hillmer, Axel M
    Tan, Min-Han
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Computational Bioscience Research Center (CBRC)
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Date
    2016-06-29
    Online Publication Date
    2016-06-29
    Print Publication Date
    2016-06-29
    Permanent link to this record
    http://hdl.handle.net/10754/615874
    
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    Abstract
    Clusters of tumor cells are often observed in the blood of cancer patients. These structures have been described as malignant entities for more than 50 years, although their comprehensive characterization is lacking. Contrary to current consensus, we demonstrate that a discrete population of circulating cell clusters isolated from the blood of colorectal cancer patients are not cancerous but consist of tumor-derived endothelial cells. These clusters express both epithelial and mesenchymal markers, consistent with previous reports on circulating tumor cell (CTC) phenotyping. However, unlike CTCs, they do not mirror the genetic variations of matched tumors. Transcriptomic analysis of single clusters revealed that these structures exhibit an endothelial phenotype and can be traced back to the tumor endothelium. Further results show that tumor-derived endothelial clusters do not form by coagulation or by outgrowth of single circulating endothelial cells, supporting a direct release of clusters from the tumor vasculature. The isolation and enumeration of these benign clusters distinguished healthy volunteers from treatment-naïve as well as pathological early-stage (≤IIA) colorectal cancer patients with high accuracy, suggesting that tumor-derived circulating endothelial cell clusters could be used as a means of noninvasive screening for colorectal cancer. In contrast to CTCs, tumor-derived endothelial cell clusters may also provide important information about the underlying tumor vasculature at the time of diagnosis, during treatment, and throughout the course of the disease.
    Citation
    Tumor-derived circulating endothelial cell clusters in colorectal cancer. 2016, 8 (345):345ra89 Sci Transl Med
    Publisher
    American Association for the Advancement of Science (AAAS)
    Journal
    Science Translational Medicine
    DOI
    10.1126/scitranslmed.aad7369
    PubMed ID
    27358499
    ae974a485f413a2113503eed53cd6c53
    10.1126/scitranslmed.aad7369
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

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