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    Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery

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    Type
    Article
    Authors
    Yassine, Omar cc
    Li, Erqiang cc
    Alfadhel, Ahmed cc
    Zaher, A.
    Kavaldzhiev, Mincho cc
    Thoroddsen, Sigurdur T cc
    Kosel, Jürgen cc
    KAUST Department
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Electrical Engineering Program
    High-Speed Fluids Imaging Laboratory
    Mechanical Engineering Program
    Physical Science and Engineering (PSE) Division
    Sensing, Magnetism and Microsystems Lab
    Date
    2016-05-26
    Online Publication Date
    2016-05-26
    Print Publication Date
    2016
    Permanent link to this record
    http://hdl.handle.net/10754/614899
    
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    Abstract
    Responsive microgel poly(N-isopropylacrylamide) or PNIPAM is a gel that can swell or shrink in response to external stimuli (temperature, pH, etc.). In this work, a nanocomposite gel is developed consisting of PNIPAM and magnetic iron oxide nanobeads for controlled release of liquids (like drugs) upon exposure to an alternating magnetic field. Microparticles of the nanocomposite are fabricated efficiently with a monodisperse size distribution and a diameter ranging from 20 to 500 µ m at a rate of up to 1 kHz using a simple and inexpensive microfluidic system. The nanocomposite is heated through magnetic losses, which is exploited for a remotely stimulated liquid release. The efficiency of the microparticles for controlled drug release applications is tested with a solution of Rhodamine B as a liquid drug model. In continuous and pulsatile mode, a release of 7% and 80% was achieved, respectively. Compared to external thermal actuation that heats the entire surrounding or embedded heaters that need complex fabrication steps, the magnetic actuation provides localized heating and is easy to implement with our microfluidic fabrication method.
    Citation
    Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery 2016, 2016:1 International Journal of Polymer Science
    Sponsors
    Research reported in this publication was supported by King Abdullah University of Science and Technology (KAUST). E. Q. Li is grateful for a SABIC Postdoctoral Fellowship.
    Publisher
    Hindawi Limited
    Journal
    International Journal of Polymer Science
    DOI
    10.1155/2016/1219469
    Additional Links
    http://www.hindawi.com/journals/ijps/2016/1219469/
    ae974a485f413a2113503eed53cd6c53
    10.1155/2016/1219469
    Scopus Count
    Collections
    Articles; Physical Science and Engineering (PSE) Division; Electrical and Computer Engineering Program; Mechanical Engineering Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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