Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery
Type
ArticleAuthors
Yassine, Omar
Li, Erqiang

Alfadhel, Ahmed

Zaher, A.
Kavaldzhiev, Mincho

Thoroddsen, Sigurdur T

Kosel, Jürgen

KAUST Department
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) DivisionElectrical Engineering Program
High-Speed Fluids Imaging Laboratory
Mechanical Engineering Program
Physical Science and Engineering (PSE) Division
Sensing, Magnetism and Microsystems Lab
Date
2016-05-26Online Publication Date
2016-05-26Print Publication Date
2016Permanent link to this record
http://hdl.handle.net/10754/614899
Metadata
Show full item recordAbstract
Responsive microgel poly(N-isopropylacrylamide) or PNIPAM is a gel that can swell or shrink in response to external stimuli (temperature, pH, etc.). In this work, a nanocomposite gel is developed consisting of PNIPAM and magnetic iron oxide nanobeads for controlled release of liquids (like drugs) upon exposure to an alternating magnetic field. Microparticles of the nanocomposite are fabricated efficiently with a monodisperse size distribution and a diameter ranging from 20 to 500 µ m at a rate of up to 1 kHz using a simple and inexpensive microfluidic system. The nanocomposite is heated through magnetic losses, which is exploited for a remotely stimulated liquid release. The efficiency of the microparticles for controlled drug release applications is tested with a solution of Rhodamine B as a liquid drug model. In continuous and pulsatile mode, a release of 7% and 80% was achieved, respectively. Compared to external thermal actuation that heats the entire surrounding or embedded heaters that need complex fabrication steps, the magnetic actuation provides localized heating and is easy to implement with our microfluidic fabrication method.Citation
Magnetically Triggered Monodispersed Nanocomposite Fabricated by Microfluidic Approach for Drug Delivery 2016, 2016:1 International Journal of Polymer ScienceSponsors
Research reported in this publication was supported by King Abdullah University of Science and Technology (KAUST). E. Q. Li is grateful for a SABIC Postdoctoral Fellowship.Publisher
Hindawi LimitedAdditional Links
http://www.hindawi.com/journals/ijps/2016/1219469/ae974a485f413a2113503eed53cd6c53
10.1155/2016/1219469