Highly Efficient Thermoresponsive Nanocomposite for Controlled Release Applications
Perez, Jose E.
Contreras, Maria F.
Thoroddsen, Sigurdur T
Khashab, Niveen M.
KAUST DepartmentAdvanced Membranes and Porous Materials Research Center
Biological and Environmental Sciences and Engineering (BESE) Division
Chemical Science Program
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Electrical Engineering Program
High-Speed Fluids Imaging Laboratory
Mechanical Engineering Program
Physical Science and Engineering (PSE) Division
Sensing, Magnetism and Microsystems Lab
Smart Hybrid Materials (SHMs) lab
Online Publication Date2016-06-23
Print Publication Date2016-09
Permanent link to this recordhttp://hdl.handle.net/10754/614805
MetadataShow full item record
AbstractHighly efficient magnetic release from nanocomposite microparticles is shown, which are made of Poly (N-isopropylacrylamide) hydrogel with embedded iron nanowires. A simple microfluidic technique was adopted to fabricate the microparticles with a high control of the nanowire concentration and in a relatively short time compared to chemical synthesis methods. The thermoresponsive microparticles were used for the remotely triggered release of Rhodamine (B). With a magnetic field of only 1 mT and 20 kHz a drug release of 6.5% and 70% was achieved in the continuous and pulsatile modes, respectively. Those release values are similar to the ones commonly obtained using superparamagnetic beads but accomplished with a magnetic field of five orders of magnitude lower power. The high efficiency is a result of the high remanent magnetization of the nanowires, which produce a large torque when exposed to a magnetic field. This causes the nanowires to vibrate, resulting in friction losses and heating. For comparison, microparticles with superparamagnetic beads were also fabricated and tested; while those worked at 73 mT and 600 kHz, no release was observed at the low field conditions. Cytotoxicity assays showed similar and high cell viability for microparticles with nanowires and beads.
CitationHighly Efficient Thermoresponsive Nanocomposite for Controlled Release Applications 2016, 6:28539 Scientific Reports
SponsorsResearch reported in this publication was supported by the King Abdullah University of Science and Technology (KAUST). EQL is grateful for a SABIC Postdoctoral Fellowship.
CollectionsArticles; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Advanced Membranes and Porous Materials Research Center; Physical Science and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Electrical Engineering Program; Chemical Science Program; Mechanical Engineering Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
- Triggered Release from Thermoresponsive Polymersomes with Superparamagnetic Membranes.
- Authors: Bixner O, Kurzhals S, Virk M, Reimhult E
- Issue date: 2016 Jan 6
- Magnetic hydrogel nanocomposites as remote controlled microfluidic valves.
- Authors: Satarkar NS, Zhang W, Eitel RE, Hilt JZ
- Issue date: 2009 Jun 21
- Iron Oxide Nanocrystals for Magnetic Hyperthermia Applications.
- Authors: Armijo LM, Brandt YI, Mathew D, Yadav S, Maestas S, Rivera AC, Cook NC, Withers NJ, Smolyakov GA, Adolphi NL, Monson TC, Huber DL, Smyth HD, Osiński M
- Issue date: 2012 May 7
- Hydrophilic Hollow Molecularly Imprinted Polymer Microparticles with Photo- and Thermoresponsive Template Binding and Release Properties in Aqueous Media.
- Authors: Li C, Ma Y, Niu H, Zhang H
- Issue date: 2015 Dec 16
- Non-chemotoxic induction of cancer cell death using magnetic nanowires.
- Authors: Contreras MF, Sougrat R, Zaher A, Ravasi T, Kosel J
- Issue date: 2015