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    Highly Efficient Thermoresponsive Nanocomposite for Controlled Release Applications

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    Type
    Article
    Authors
    Yassine, Omar cc
    Zaher, Amir cc
    Li, Erqiang cc
    Alfadhel, Ahmed cc
    Perez, Jose E. cc
    Kavaldzhiev, Mincho cc
    Contreras, Maria F. cc
    Thoroddsen, Sigurdur T cc
    Khashab, Niveen M. cc
    Kosel, Jürgen cc
    KAUST Department
    Advanced Membranes and Porous Materials Research Center
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Chemical Science Program
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Electrical Engineering Program
    High-Speed Fluids Imaging Laboratory
    Mechanical Engineering Program
    Physical Science and Engineering (PSE) Division
    Sensing, Magnetism and Microsystems Lab
    Smart Hybrid Materials (SHMs) lab
    Date
    2016-06-23
    Online Publication Date
    2016-06-23
    Print Publication Date
    2016-09
    Permanent link to this record
    http://hdl.handle.net/10754/614805
    
    Metadata
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    Abstract
    Highly efficient magnetic release from nanocomposite microparticles is shown, which are made of Poly (N-isopropylacrylamide) hydrogel with embedded iron nanowires. A simple microfluidic technique was adopted to fabricate the microparticles with a high control of the nanowire concentration and in a relatively short time compared to chemical synthesis methods. The thermoresponsive microparticles were used for the remotely triggered release of Rhodamine (B). With a magnetic field of only 1 mT and 20 kHz a drug release of 6.5% and 70% was achieved in the continuous and pulsatile modes, respectively. Those release values are similar to the ones commonly obtained using superparamagnetic beads but accomplished with a magnetic field of five orders of magnitude lower power. The high efficiency is a result of the high remanent magnetization of the nanowires, which produce a large torque when exposed to a magnetic field. This causes the nanowires to vibrate, resulting in friction losses and heating. For comparison, microparticles with superparamagnetic beads were also fabricated and tested; while those worked at 73 mT and 600 kHz, no release was observed at the low field conditions. Cytotoxicity assays showed similar and high cell viability for microparticles with nanowires and beads.
    Citation
    Highly Efficient Thermoresponsive Nanocomposite for Controlled Release Applications 2016, 6:28539 Scientific Reports
    Sponsors
    Research reported in this publication was supported by the King Abdullah University of Science and Technology (KAUST). EQL is grateful for a SABIC Postdoctoral Fellowship.
    Publisher
    Springer Nature
    Journal
    Scientific Reports
    DOI
    10.1038/srep28539
    PubMed ID
    27335342
    Additional Links
    http://www.nature.com/articles/srep28539
    ae974a485f413a2113503eed53cd6c53
    10.1038/srep28539
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Advanced Membranes and Porous Materials Research Center; Physical Science and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Electrical Engineering Program; Chemical Science Program; Mechanical Engineering Program; Sensing, Magnetism and Microsystems Lab; Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division

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