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dc.contributor.authorHurst, Laurence D.
dc.contributor.authorGhanbarian, Avazeh T.
dc.contributor.authorForrest, Alistair R.R.
dc.contributor.authorHuminiecki, Lukasz
dc.contributor.authorRehli, Michael
dc.contributor.authorKenneth Baillie, J.
dc.contributor.authorde Hoon, Michiel J.L.
dc.contributor.authorHaberle, Vanja
dc.contributor.authorLassmann, Timo
dc.contributor.authorKulakovskiy, Ivan V.
dc.contributor.authorLizio, Marina
dc.contributor.authorItoh, Masayoshi
dc.contributor.authorAndersson, Robin
dc.contributor.authorMungall, Christopher J.
dc.contributor.authorMeehan, Terrence F.
dc.contributor.authorSchmeier, Sebastian
dc.contributor.authorBertin, Nicolas
dc.contributor.authorJørgensen, Mette
dc.contributor.authorDimont, Emmanuel
dc.contributor.authorArner, Erik
dc.contributor.authorSchmidl, Christian
dc.contributor.authorSchaefer, Ulf
dc.contributor.authorMedvedeva, Yulia
dc.contributor.authorPlessy, Charles
dc.contributor.authorVitezic, Morana
dc.contributor.authorSeverin, Jessica
dc.contributor.authorSemple, Colin A.
dc.contributor.authorIshizu, Yuri
dc.contributor.authorYoung, Robert S.
dc.contributor.authorFrancescatto, Margherita
dc.contributor.authorAlam, Intikhab
dc.contributor.authorAlbanese, Davide
dc.contributor.authorAltschuler, Gabriel M.
dc.contributor.authorArakawa, Takahiro
dc.contributor.authorArcher, John A.C.
dc.contributor.authorArner, Peter
dc.contributor.authorBabina, Magda
dc.contributor.authorBaker, Sarah
dc.contributor.authorBalwierz, Piotr J.
dc.contributor.authorBeckhouse, Anthony G.
dc.contributor.authorPradhan, Swati Bhatt
dc.contributor.authorBlake, Judith A.
dc.contributor.authorBlumenthal, Antje
dc.contributor.authorBodega, Beatrice
dc.contributor.authorBonetti, Alessandro
dc.contributor.authorBriggs, James
dc.contributor.authorBrombacher, Frank
dc.contributor.authorMaxwell Burroughs, A.
dc.contributor.authorCalifano, Andrea
dc.contributor.authorCannistraci, Carlo
dc.contributor.authorCarbajo, Daniel
dc.contributor.authorChen, Yun
dc.contributor.authorChierici, Marco
dc.contributor.authorCiani, Yari
dc.contributor.authorClevers, Hans C.
dc.contributor.authorDalla, Emiliano
dc.contributor.authorDavis, Carrie A.
dc.contributor.authorDetmar, Michael
dc.contributor.authorDiehl, Alexander D.
dc.contributor.authorDohi, Taeko
dc.contributor.authorDrabløs, Finn
dc.contributor.authorEdge, Albert S.B.
dc.contributor.authorEdinger, Matthias
dc.contributor.authorEkwall, Karl
dc.contributor.authorEndoh, Mitsuhiro
dc.contributor.authorEnomoto, Hideki
dc.contributor.authorFagiolini, Michela
dc.contributor.authorFairbairn, Lynsey
dc.contributor.authorFang, Hai
dc.contributor.authorFarach-Carson, Mary C.
dc.contributor.authorFaulkner, Geoffrey J.
dc.contributor.authorFavorov, Alexander V.
dc.contributor.authorFisher, Malcolm E.
dc.contributor.authorFrith, Martin C.
dc.contributor.authorFujita, Rie
dc.contributor.authorFukuda, Shiro
dc.contributor.authorFurlanello, Cesare
dc.contributor.authorFuruno, Masaaki
dc.contributor.authorFurusawa, Jun ichi
dc.contributor.authorGeijtenbeek, Teunis B.
dc.contributor.authorGibson, Andrew
dc.contributor.authorGingeras, Thomas
dc.contributor.authorGoldowitz, Daniel
dc.contributor.authorGough, Julian
dc.contributor.authorGuhl, Sven
dc.contributor.authorGuler, Reto
dc.contributor.authorGustincich, Stefano
dc.contributor.authorHa, Thomas J.
dc.contributor.authorHamaguchi, Masahide
dc.contributor.authorHara, Mitsuko
dc.contributor.authorHarbers, Matthias
dc.contributor.authorHarshbarger, Jayson
dc.contributor.authorHasegawa, Akira
dc.contributor.authorHasegawa, Yuki
dc.contributor.authorHashimoto, Takehiro
dc.contributor.authorHerlyn, Meenhard
dc.contributor.authorHitchens, Kelly J.
dc.contributor.authorHo Sui, Shannan J.
dc.contributor.authorHofmann, Oliver M.
dc.contributor.authorHoof, Ilka
dc.contributor.authorHori, Fumi
dc.contributor.authorHuminiecki, Lukasz
dc.contributor.authorIida, Kei
dc.contributor.authorIkawa, Tomokatsu
dc.contributor.authorJankovic, Boris R.
dc.contributor.authorJia, Hui
dc.contributor.authorJoshi, Anagha
dc.contributor.authorJurman, Giuseppe
dc.contributor.authorKaczkowski, Bogumil
dc.contributor.authorKai, Chieko
dc.contributor.authorKaida, Kaoru
dc.contributor.authorKaiho, Ai
dc.contributor.authorKajiyama, Kazuhiro
dc.contributor.authorKanamori, Mutsumi Katayama
dc.contributor.authorKasianov, Artem S.
dc.contributor.authorKasukawa, Takeya
dc.contributor.authorKatayama, Shintaro
dc.contributor.authorKato, Sachi
dc.contributor.authorKawaguchi, Shuji
dc.contributor.authorKawamoto, Hiroshi
dc.contributor.authorKawamura, Yuki I.
dc.contributor.authorKawashima, Tsugumi
dc.contributor.authorKempfle, Judith S.
dc.contributor.authorKenna, Tony J.
dc.contributor.authorKere, Juha
dc.contributor.authorKhachigian, Levon M.
dc.contributor.authorKitamura, Toshio
dc.contributor.authorPeter Klinken, S.
dc.contributor.authorKnox, Alan J.
dc.contributor.authorKojima, Miki
dc.contributor.authorKojima, Soichi
dc.contributor.authorKondo, Naoto
dc.contributor.authorKoseki, Haruhiko
dc.contributor.authorKoyasu, Shigeo
dc.contributor.authorKrampitz, Sarah
dc.contributor.authorKubosaki, Atsutaka
dc.contributor.authorKwon, Andrew T.
dc.contributor.authorLaros, Jeroen F.J.
dc.contributor.authorLee, Weonju
dc.contributor.authorLennartsson, Andreas
dc.contributor.authorLi, Kang
dc.contributor.authorLilje, Berit
dc.contributor.authorLipovich, Leonard
dc.contributor.authorMackay, Alan sim
dc.contributor.authorManabe, Riichiroh
dc.contributor.authorMar, Jessica C.
dc.contributor.authorMarchand, Benoit
dc.contributor.authorMathelier, Anthony
dc.contributor.authorMejhert, Niklas
dc.contributor.authorMeynert, Alison
dc.contributor.authorMizuno, Yosuke
dc.contributor.authorde Lima Morais, David A.
dc.contributor.authorMorikawa, Hiromasa
dc.contributor.authorMorimoto, Mitsuru
dc.contributor.authorMoro, Kazuyo
dc.contributor.authorMotakis, Efthymios
dc.contributor.authorMotohashi, Hozumi
dc.contributor.authorMummery, Christine L.
dc.contributor.authorMurata, Mitsuyoshi
dc.contributor.authorNagao, Sayaka Sato
dc.contributor.authorNakachi, Yutaka
dc.contributor.authorNakahara, Fumio
dc.contributor.authorNakamura, Toshiyuki
dc.contributor.authorNakamura, Yukio
dc.contributor.authorNakazato, Kenichi
dc.contributor.authorVan Nimwegen, Erik
dc.contributor.authorNinomiya, Noriko
dc.contributor.authorNishiyori, Hiromi
dc.contributor.authorNoma, Shohei
dc.contributor.authorNozaki, Tadasuke
dc.contributor.authorOgishima, Soichi
dc.contributor.authorOhkura, Naganari
dc.contributor.authorOhmiya, Hiroko
dc.contributor.authorOhno, Hiroshi
dc.contributor.authorOhshima, Mitsuhiro
dc.contributor.authorOkada, Mariko Hatakeyama
dc.contributor.authorOkazaki, Yasushi
dc.contributor.authorOrlando, Valerio
dc.contributor.authorOvchinnikov, Dmitry A.
dc.contributor.authorPain, Arnab
dc.contributor.authorPassier, Robert
dc.contributor.authorPatrikakis, Margaret
dc.contributor.authorPersson, Helena
dc.contributor.authorPiazza, Silvano
dc.contributor.authorPrendergast, James G.D.
dc.contributor.authorRackham, Owen J.L.
dc.contributor.authorRamilowski, Jordan A.
dc.contributor.authorRashid, Mamoon
dc.contributor.authorRavasi, Timothy
dc.contributor.authorRizzu, Patrizia
dc.contributor.authorRoncador, Marco
dc.contributor.authorRoy, Sugata
dc.contributor.authorRye, Morten B.
dc.contributor.authorSaijyo, Eri
dc.contributor.authorSajantila, Antti
dc.contributor.authorSaka, Akiko
dc.contributor.authorSakaguchi, Shimon
dc.contributor.authorSakai, Mizuho
dc.contributor.authorSato, Hiroki
dc.contributor.authorSatoh, Hironori
dc.contributor.authorSavvi, Suzana
dc.contributor.authorSaxena, Alka
dc.contributor.authorSchneider, Claudio
dc.contributor.authorSchultes, Erik A.
dc.contributor.authorSchulze-Tanzil, Gundula G.
dc.contributor.authorSchwegmann, Anita
dc.contributor.authorSengstag, Thierry
dc.contributor.authorSheng, Guojun
dc.contributor.authorShimoji, Hisashi
dc.contributor.authorShimoni, Yishai
dc.contributor.authorShin, Jay W.
dc.contributor.authorSimon, Christophe
dc.contributor.authorSugiyama, Daisuke
dc.contributor.authorSugiyama, Takaaki
dc.contributor.authorSuzuki, Masanori
dc.contributor.authorSuzuki, Naoko
dc.contributor.authorSwoboda, Rolf K.
dc.contributor.author't Hoen, Peter A.C.
dc.contributor.authorTagami, Michihira
dc.contributor.authorTakahashi, Naoko
dc.contributor.authorTakai, Jun
dc.contributor.authorTanaka, Hiroshi
dc.contributor.authorTatsukawa, Hideki
dc.contributor.authorTatum, Zuotian
dc.contributor.authorThompson, Mark
dc.contributor.authorToyoda, Hiroo
dc.contributor.authorToyoda, Tetsuro
dc.contributor.authorValen, Eivind
dc.contributor.authorvan de Wetering, Marc
dc.contributor.authorVan Den Berg, Linda M.
dc.contributor.authorVerardo, Roberto
dc.contributor.authorVijayan, Dipti
dc.contributor.authorVorontsov, Ilya E.
dc.contributor.authorWasserman, Wyeth W.
dc.contributor.authorWatanabe, Shoko
dc.contributor.authorWells, Christine A.
dc.contributor.authorWinteringham, Louise N.
dc.contributor.authorWolvetang, Ernst
dc.contributor.authorWood, Emily J.
dc.contributor.authorYamaguchi, Yoko
dc.contributor.authorYamamoto, Masayuki
dc.contributor.authorYoneda, Misako
dc.contributor.authorYonekura, Yohei
dc.contributor.authorYoshida, Shigehiro
dc.contributor.authorZabierowski, Suzan E.
dc.contributor.authorZhang, Peter G.
dc.contributor.authorZhao, Xiaobei
dc.contributor.authorZucchelli, Silvia
dc.contributor.authorSummers, Kim M.
dc.contributor.authorSuzuki, Harukazu
dc.contributor.authorDaub, Carsten O.
dc.contributor.authorKawai, Jun
dc.contributor.authorHeutink, Peter
dc.contributor.authorHide, Winston
dc.contributor.authorFreeman, Tom C.
dc.contributor.authorLenhard, Boris
dc.contributor.authorBajic, Vladimir B.
dc.contributor.authorTaylor, Martin S.
dc.contributor.authorMakeev, Vsevolod J.
dc.contributor.authorSandelin, Albin
dc.contributor.authorHume, David A.
dc.contributor.authorCarninci, Piero
dc.contributor.authorHayashizaki, Yoshihide
dc.date.accessioned2016-06-23T11:14:58Z
dc.date.available2016-06-23T11:14:58Z
dc.date.issued2015-12-18
dc.identifier.citationHurst, L. D., Ghanbarian, A. T., Forrest, A. R. R., & Huminiecki, L. (2015). The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome. PLOS Biology, 13(12), e1002315. doi:10.1371/journal.pbio.1002315
dc.identifier.issn1545-7885
dc.identifier.issn1544-9173
dc.identifier.doi10.1371/journal.pbio.1002315
dc.identifier.urihttp://hdl.handle.net/10754/614423
dc.description.abstractX chromosomes are unusual in many regards, not least of which is their nonrandom gene content. The causes of this bias are commonly discussed in the context of sexual antagonism and the avoidance of activity in the male germline. Here, we examine the notion that, at least in some taxa, functionally biased gene content may more profoundly be shaped by limits imposed on gene expression owing to haploid expression of the X chromosome. Notably, if the X, as in primates, is transcribed at rates comparable to the ancestral rate (per promoter) prior to the X chromosome formation, then the X is not a tolerable environment for genes with very high maximal net levels of expression, owing to transcriptional traffic jams. We test this hypothesis using The Encyclopedia of DNA Elements (ENCODE) and data from the Functional Annotation of the Mammalian Genome (FANTOM5) project. As predicted, the maximal expression of human X-linked genes is much lower than that of genes on autosomes: on average, maximal expression is three times lower on the X chromosome than on autosomes. Similarly, autosome-to-X retroposition events are associated with lower maximal expression of retrogenes on the X than seen for X-to-autosome retrogenes on autosomes. Also as expected, X-linked genes have a lesser degree of increase in gene expression than autosomal ones (compared to the human/Chimpanzee common ancestor) if highly expressed, but not if lowly expressed. The traffic jam model also explains the known lower breadth of expression for genes on the X (and the Z of birds), as genes with broad expression are, on average, those with high maximal expression. As then further predicted, highly expressed tissue-specific genes are also rare on the X and broadly expressed genes on the X tend to be lowly expressed, both indicating that the trend is shaped by the maximal expression level not the breadth of expression per se. Importantly, a limit to the maximal expression level explains biased tissue of expression profiles of X-linked genes. Tissues whose tissue-specific genes are very highly expressed (e.g., secretory tissues, tissues abundant in structural proteins) are also tissues in which gene expression is relatively rare on the X chromosome. These trends cannot be fully accounted for in terms of alternative models of biased expression. In conclusion, the notion that it is hard for genes on the Therian X to be highly expressed, owing to transcriptional traffic jams, provides a simple yet robustly supported rationale of many peculiar features of X’s gene content, gene expression, and evolution.
dc.description.sponsorshipFANTOM5 was made possible by a Research Grant for RIKEN Omics Science Center from MEXT to YH and a Grant of the Innovative Cell Biology by Innovative Technology (Cell Innovation Program) from the MEXT, Japan to YH. Vetenskapsrådet's project grant 2011-5893 funded LH. European Research Council's grant (ERC-2014-ADG 669207) supports LDH. LDH would also like to acknowledge a Medical Research Council's award MR/L007215/1. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.language.isoen
dc.publisherPublic Library of Science (PLoS)
dc.relation.urlhttps://dx.plos.org/10.1371/journal.pbio.1002315
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. http://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleThe Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome
dc.typeArticle
dc.contributor.departmentAcademic Affairs
dc.contributor.departmentApplied Mathematics and Computational Science Program
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentIntegrative Systems Biology Lab
dc.contributor.departmentOffice of the VP
dc.contributor.departmentPathogen Genomics Laboratory
dc.contributor.departmentRed Sea Research Center (RSRC)
dc.contributor.departmentResearch Applications
dc.contributor.departmentResearch Computing
dc.identifier.journalPLoS Biology
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionThe Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
dc.contributor.institutionCenter for Life Science Technologies (CLST), Yokohama, Japan
dc.contributor.institutionThe Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden
dc.contributor.institutionDepartment of Cell and Molecular Biology, Karolinska Institutet, P.O. Box 285, Stockholm, SE-171 77, Sweden
dc.contributor.institutionScience for Life Laboratory, Stockholm, Sweden
dc.contributor.institutionThe Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
dc.contributor.institutionBioinformatics Infrastructure for Life Sciences (BILS), Stockholm, Sweden
dc.contributor.institutionDepartment of Internal Medicine III, University Hospital Regensburg, F.-J.-Strauss Allee 11, Regensburg, D-93042, Germany
dc.contributor.institutionRegensburg Centre for Interventional Immunology (RCI), Regensburg, D-93042, Germany
dc.contributor.institutionThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh, Midlothian, Scotland, EH25 9RG, United Kingdom
dc.contributor.institutionRIKEN Omics Science Center (OSC), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan
dc.contributor.institutionRIKEN Center for Life Science Technologies (Division of Genomic Technologies), Japan
dc.contributor.institutionInstitute of Clinical Sciences, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, United Kingdom
dc.contributor.institutionDepartment of Biology, University of Bergen, Thormøhlensgate 53, Bergen, NO-5006, Norway
dc.contributor.institutionDepartment of Computational Systems Biology, Vavilov Institute of General Genetics (VIGG), Gubkin str. 3, Moscow, 119991, Russian Federation
dc.contributor.institutionEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov str. 32, Moscow, 119991, Russian Federation
dc.contributor.institutionRIKEN Preventive Medicine and Diagnosis Innovation Program, Japan
dc.contributor.institutionThe Bioinformatics Centre, Department of Biology and BRIC, University of Copenhagen, Ole Maaloes Vej 5, Copenhagen, DK 2200, Denmark
dc.contributor.institutionGenomics Division, Lawrence Berkeley National Laboratory, 84R01, 1 Cyclotron Road, Berkeley, CA, 94720, United States
dc.contributor.institutionMouse Informatics, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, United Kingdom
dc.contributor.institutionInstitute of Natural and Mathematical Sciences, Massey University, Auckland, New Zealand
dc.contributor.institutionDepartment of Biostatistics, Harvard School of Public Health, 655 Huntington Ave, Boston, MA, 02115, United States
dc.contributor.institutionMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (MRCIGMM), University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, United Kingdom
dc.contributor.institutionDepartment of Clinical Genetics, VU University Medical Center Amsterdam, Van der Boechorststraat 7, Amsterdam, 1081 BT, Netherlands
dc.contributor.institutionGraduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, Rua de Jorge Viterbo Ferreira n. 228, Porto, 4050-313, Portugal
dc.contributor.institutionPredictive Models for Biomedicine and Environment, Fondazione Bruno Kessler, via Sommarive 18, Trento TN, 38123, Italy
dc.contributor.institutionDepartment of Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, Huddinge, SE-141 86, Sweden
dc.contributor.institutionDepartment of Dermatology and Allergy, Charité Campus Mitte, Universitätsmedizin Berlin, Chariteplatz 1, Berlin, 10117, Germany
dc.contributor.institutionBiozentrum, University of Basel, Klingelbergstrasse 50-70, Basel, 4056, Switzerland
dc.contributor.institutionAustralian Institute for Bioengineering and Nanotechnology (AIBN), University of Queensland, Brisbane St Lucia, QLD, 4072, Australia
dc.contributor.institutionAustralian Infectious Diseases Research Centre (AID), University of Queensland, Brisbane St Lucia, QLD, 4072, Australia
dc.contributor.institutionDepartment of Biological Sciences, University of Delaware, Newark, DE, United States
dc.contributor.institutionBioinformatics and Computational Biology, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, United States
dc.contributor.institutionFondazione Santa Lucia, Dulbecco Telethon Institute, via del Fosso di Fiorano 64, Rome RM, 00143, Italy
dc.contributor.institutionImmunology and Infectious Disease, International Centre for Genetic Engineering & Biotechnology (ICGEB) Cape Town component, Anzio Road, Observatory, Cape Town, 7925, South Africa
dc.contributor.institutionDivision of Immunology, Institute of Infectious Diseases and Molecular Medicine (IIDMM), University of Cape Town, Anzio Road, Observatory, Cape Town, 7925, South Africa
dc.contributor.institutionColumbia Initiative in Systems Biology, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center, 1130 St. Nicholas Ave, New York, NY, 10032, United States
dc.contributor.institutionDepartment of Biochemistry and Mol. Biophysics, Columbia University Medical Center, 701 West 168th Street, New York, NY, 10032, United States
dc.contributor.institutionDepartment of Biomedical Informatics, Columbia University Medical Center, 622 West 168th St. VC5, New York, NY, 10032, United States
dc.contributor.institutionInstitute of Cancer Genetics, Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center, 1130 St. Nicholas Ave, New York, NY, 10032, United States
dc.contributor.institutionBiomedical Cybernetics Group, Biotechnology Center (BIOTEC), Technische Universität Dresden, Dresden, Germany
dc.contributor.institutionSystems and Computational Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave Price 253, New York, NY, 10461, United States
dc.contributor.institutionLaboratorio Nazionale del Consorzio Interuniversitario per le Biotecnologie (LNCIB), Padriciano 99, Trieste TS, 34149, Italy
dc.contributor.institutionHubrecht Institute, Uppsalalaan 8, CT Utrecht, 3584, Netherlands
dc.contributor.institutionThe Royal Netherlands Academy of Arts and Sciences, P.O. Box 19121, GC Amsterdam, NL-1000, Netherlands
dc.contributor.institutionUniversity Medical Centre Utrecht, Postbus 85500, GA Utrecht, 3508, Netherlands
dc.contributor.institutionGenomics, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY, 11797, United States
dc.contributor.institutionInstitute of Pharmaceutical Sciences, ETH Zurich, Wolfgang-Pauli-Strasse 10, HCI H 303, Zurich, 8093, Switzerland
dc.contributor.institutionDepartment of Neurology, University at Buffalo School of Medicine and Biomedical Sciences, New York State Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, NY, 14203, United States
dc.contributor.institutionGastroenterology, Research Center for Hepatitis and Immunology Research Institute, National Center for Global Health and Medicine, 1-7-1 Kohnodai, Ichikawa, Chiba, 272-8516, Japan
dc.contributor.institutionDepartment of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), P.O. Box 8905, Trondheim, NO-7491, Norway
dc.contributor.institutionDepartment of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Eaton-Peabody Lab, 243 Charles Street, Boston, MA, 02114, United States
dc.contributor.institutionDepartment of Biosciences and Nutrition, Center for Biosciences, Karolinska Institutet, Hälsovägen 7-9, Huddinge, SE-141 83, Sweden
dc.contributor.institutionRIKEN Research Center for Allergy and Immunology (RCAI), 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa, 230-0045, Japan
dc.contributor.institutionRIKEN Center for Developmental Biology (CDB), 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan
dc.contributor.institutionFM Kirby Neurobiology Center, Children’s Hospital Boston, Harvard. Medical School, 300 Longwood Ave, Boston, MA, 02115, United States
dc.contributor.institutionDepartment of Computer Science, University of Bristol, Merchant Venturers Building, Woodland Road, Clifton, BS8 1UB, United Kingdom
dc.contributor.institutionDepartment of Biochemistry and Cell Biology, Rice University, Houston, TX, United States
dc.contributor.institutionCancer Biology Program, Mater Medical Research Institute, Raymond Tce, South Brisbane, QLD, 4101, Australia
dc.contributor.institutionDepartment of Oncology, Division of Oncology, Biostatistics and Bioinformatics, Johns Hopkins University School of Medicine, 550 N Broadway, Baltimore, MD, 21205, United States
dc.contributor.institutionLaboratory of Bioinformatics, Research Institute of Genetics and Selection of Industrial Microorganisms, 1-st Dorozhniy pr., 1, Moscow, 117545, Russian Federation
dc.contributor.institutionComputational Biology Research Center, National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo, 135-0064, Japan
dc.contributor.institutionDepartment of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan
dc.contributor.institutionDepartment of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan
dc.contributor.institutionExperimental Immunology, Academic Medical Center—University of Amsterdam, Meibergdreef 9, Amsterdam, 1105 AZ, Netherlands
dc.contributor.institutionDepartment of Human Genetics, Leiden University Medical Center, Einthovenweg 20, Leiden, 2333 ZC, Netherlands
dc.contributor.institutionDepartment of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada
dc.contributor.institutionNeuroscience, SISSA, via Bonomea 265, Trieste TS, 34136, Italy
dc.contributor.institutionExperimental Immunology, Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan
dc.contributor.institutionRIKEN Advanced Science Institute (ASI), 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan
dc.contributor.institutionMelanoma Research Center, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, United States
dc.contributor.institutionRIKEN Bioinformatics And Systems Engineering Division (BASE), 1-7-22 Suehiro, Tsurumi, Yokohama, Kanagawa, 230-0045, Japan
dc.contributor.institutionCenter for Molecular Medicine and Genetics, Wayne State University, 3228 Scott Hall, 540 East Canfield Street, Detroit, MI, 48201-1928, United States
dc.contributor.institutionLaboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan
dc.contributor.institutionDiamantina Institute, University of Queensland, Brisbane St Lucia, QLD, 4072, Australia
dc.contributor.institutionScience for Life Laboratory, Box 1031, Solna, SE-171 21, Sweden
dc.contributor.institutionCentre for Vascular Research, University of New South Wales, Sydney, NSW, 2052, Australia
dc.contributor.institutionDepartment of Hematopoietic Factor, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan
dc.contributor.institutionHarry Perkins Institute of Medical Research, and the Centre for Medical Research, University of Western Australia. QQ Block, QEII Medical Centre, Nedlands, Perth, WA, 6009, Australia
dc.contributor.institutionRespiratory Medicine, University of Nottingham, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham, NG5 1PB, United Kingdom
dc.contributor.institutionDermatology, School of Medicine, Kyungpook National University, 130 Dongdeok-ro, Jung-gu, Daegu, 700-721, South Korea
dc.contributor.institutionNational Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD, Australia
dc.contributor.institutionDivision of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, 350-1241, Japan
dc.contributor.institutionUniversity of Bristol, Merchant Venturers Building, Woodland Road, Clifton, BS8 1UB, United Kingdom
dc.contributor.institutionPRESTO, Japanese Science and Technology Agency (JST), 7 Gobancho, Chiyodaku, Tokyo, 102-0076, Japan
dc.contributor.institutionCenter for Radioisotope Sciences, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan
dc.contributor.institutionAnatomy and Embryology, Leiden University Medical Center, Einthovenweg 20, P.O. Box 9600, RC Leiden, 2300, Netherlands
dc.contributor.institutionDivision of Translational Research, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka, Saitama, 350-1241, Japan
dc.contributor.institutionRIKEN BioResource Center (BRC), Koyadai 3-1-1, Tsukuba, Ibaraki, 305-0074, Japan
dc.contributor.institutionDepartment of Clinical Molecular Genetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan
dc.contributor.institutionDepartment of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan
dc.contributor.institutionDepartment of Biochemistry, Ohu University School of Pharmaceutical Sciences, Misumido 31-1, Tomitamachi, Koriyama, Fukushima, 963-8611, Japan
dc.contributor.institutionHjelt Institute, Department of Forensic Medicine, University of Helsinki, Kytosuontie 11, Helsinki, 003000, Finland
dc.contributor.institutionGenomics Core Facility, Biomedical Research Centre, Guy's Hospital, London, United Kingdom
dc.contributor.institutionDepartment of Orthopedic, Trauma and Reconstructive Surgery, Charité Universitätsmedizin Berlin, Garystrasse 5, Berlin, 14195, Germany
dc.contributor.institutionCenter for Clinical and Translational Reseach, Kyushu University Hospital, Station for Collaborative Research1 4F, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan
dc.contributor.institutionNetherlands Bioinformatics Centre, 260 NBIC, P.O. Box 9101, HB Nijmegen, 6500, Netherlands
dc.contributor.institutionGraduate School of Pharmaceutical Sciences, Nagoya University, Furo-cho, Chikusa, Nagoya, Aichi, 464-8601, Japan
dc.contributor.institutionDepartment of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave, Cambridge, MA, 02138, United States
dc.contributor.institutionDepartment of Biochemistry, Nihon University School of Dentistry, 1-8-13, Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan
dc.contributor.institutionMolecular and Cellular Oncogenesis, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, United States
dc.contributor.institutionDepartment of Informatics, University of Bergen, Høgteknologisenteret, Thormøhlensgate 53, Bergen, NO-5008, Norway
dc.contributor.institutionDepartment of Biological and Medical Physics, Moscow Institute of Physics and Technology (MIPT) 9, Institutsky Per., Dolgoprudny, Moscow Region, 141700, Russian Federation
dc.identifier.volume13
dc.identifier.issue12
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
dc.identifier.pagese1002315
kaust.personSchmeier, Sebastian
kaust.personSchaefer, Ulf
kaust.personMedvedeva, Yulia
kaust.personAlam, Intikhab
kaust.personArcher, John A.C.
kaust.personCannistraci, Carlo
kaust.personCannistraci, Carlo
kaust.personJankovic, Boris R.
kaust.personMarchand, Benoit
kaust.personPain, Arnab
kaust.personPain, Arnab
kaust.personRashid, Mamoon
kaust.personRashid, Mamoon
kaust.personRavasi, Timothy
kaust.personRavasi, Timothy
kaust.personBajic, Vladimir B.
dc.identifier.eid2-s2.0-84969295765
refterms.dateFOA2018-06-14T08:10:53Z


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Except where otherwise noted, this item's license is described as This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. http://creativecommons.org/licenses/by/4.0/