Show simple item record

dc.contributor.authorSchrittwieser, Stefan
dc.contributor.authorPelaz, Beatriz
dc.contributor.authorParak, Wolfgang J.
dc.contributor.authorLentijo Mozo, Sergio
dc.contributor.authorSoulantica, Katerina
dc.contributor.authorDieckhoff, Jan
dc.contributor.authorLudwig, Frank
dc.contributor.authorGuenther, Annegret
dc.contributor.authorTschöpe, Andreas
dc.contributor.authorSchotter, Joerg
dc.date.accessioned2016-06-23T11:05:28Z
dc.date.available2016-06-23T11:05:28Z
dc.date.issued2016-06-06
dc.identifier.citationHomogeneous Biosensing Based on Magnetic Particle Labels 2016, 16 (6):828 Sensors
dc.identifier.issn1424-8220
dc.identifier.doi10.3390/s16060828
dc.identifier.urihttp://hdl.handle.net/10754/614419
dc.description.abstractThe growing availability of biomarker panels for molecular diagnostics is leading to an increasing need for fast and sensitive biosensing technologies that are applicable to point-of-care testing. In that regard, homogeneous measurement principles are especially relevant as they usually do not require extensive sample preparation procedures, thus reducing the total analysis time and maximizing ease-of-use. In this review, we focus on homogeneous biosensors for the in vitro detection of biomarkers. Within this broad range of biosensors, we concentrate on methods that apply magnetic particle labels. The advantage of such methods lies in the added possibility to manipulate the particle labels by applied magnetic fields, which can be exploited, for example, to decrease incubation times or to enhance the signal-to-noise-ratio of the measurement signal by applying frequency-selective detection. In our review, we discriminate the corresponding methods based on the nature of the acquired measurement signal, which can either be based on magnetic or optical detection. The underlying measurement principles of the different techniques are discussed, and biosensing examples for all techniques are reported, thereby demonstrating the broad applicability of homogeneous in vitro biosensing based on magnetic particle label actuation.
dc.description.sponsorshipParts of this work were supported by the European Commission (project FutureNanoNeeds to WJP) and by the European Commission FP7 NAMDIATREAM project (EU NMP4-LA-2010-246479).
dc.language.isoen
dc.publisherMDPI AG
dc.relation.urlhttp://www.mdpi.com/1424-8220/16/6/828
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.subjectbiosensor
dc.subjectmagnetic nanoparticle
dc.subjecthomogeneous assay
dc.subjectmagnetorelaxation
dc.subjectAC susceptibility
dc.subjectNMR
dc.subjectmagnetic relaxation switch
dc.subjectasynchronous magnetorotation
dc.subjectmagneto-optics
dc.subjectnanorod
dc.titleHomogeneous Biosensing Based on Magnetic Particle Labels
dc.typeArticle
dc.contributor.departmentNABLA Lab
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalSensors
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionMolecular Diagnostics, AIT Austrian Institute of Technology, Vienna1220, Austria
dc.contributor.institutionFachbereich Physik, Philipps-Universität Marburg, Marburg 35037, Germany
dc.contributor.institutionLaboratoire de Physique et Chimie des Nano-objets (LPCNO), Université de Toulouse, INSA, UPS, CNRS, Toulouse 31077, France
dc.contributor.institutionInstitute of Electrical Measurement and Fundamental Electrical Engineering, TU Braunschweig, Braunschweig 38106, Germany
dc.contributor.institutionExperimentalphysik, Universität des Saarlandes, Saarbrücken 66123, Germany
dc.contributor.institutionDiagnostic and Interventional Radiology Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personLentijo Mozo, Sergio
refterms.dateFOA2018-06-13T12:45:10Z


Files in this item

Thumbnail
Name:
sensors-16-00828.pdf
Size:
7.893Mb
Format:
PDF
Description:
Main article

This item appears in the following Collection(s)

Show simple item record