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dc.contributor.authorCroissant, Jonas
dc.contributor.authorFatieiev, Yevhen
dc.contributor.authorJulfakyan, Khachatur
dc.contributor.authorLu, Jie
dc.contributor.authorEmwas, Abdelhamid
dc.contributor.authorAnjum, Dalaver H.
dc.contributor.authorOmar, Haneen
dc.contributor.authorTamanoi, Fuyuhiko
dc.contributor.authorZink, Jeffrey
dc.contributor.authorKhashab, Niveen M.
dc.date.accessioned2016-06-14T08:04:08Z
dc.date.available2016-06-14T08:04:08Z
dc.date.issued2016-06-30
dc.identifier.citationBiodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells 2016 Chemistry - A European Journal
dc.identifier.issn09476539
dc.identifier.pmid27258139
dc.identifier.doi10.1002/chem.201601714
dc.identifier.urihttp://hdl.handle.net/10754/612998
dc.description.abstractWe describe biodegradable mesoporous hybrid NPs in the presence of proteins, and its application for drug delivery. We synthesized oxamide-phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of silica source which had a remarkably high organic content with a high surface area. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt%), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.
dc.description.sponsorshipThe authors gratefully acknowledge King Abdullah University of Science and Technology and the University of California, Los Angeles for the support of this work.
dc.language.isoen
dc.publisherWiley
dc.relation.urlhttp://doi.wiley.com/10.1002/chem.201601714
dc.rightsThis is the peer reviewed version of the following article: Croissant, J., Fatieiev, Y., Julfakyan, K., Lu, J., Emwas, A., Anjum, D., Omar, H., Tamanoi, F., Zink, J. and Khashab, N. (2016), Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells. Chem. Eur. J., which has been published in final form at http://doi.wiley.com/10.1002/chem.201601714. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
dc.titleBiodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells
dc.typeArticle
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentChemical Science Program
dc.contributor.departmentImaging and Characterization Core Lab
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentSmart Hybrid Materials (SHMs) lab
dc.identifier.journalChemistry - A European Journal
dc.eprint.versionPost-print
dc.contributor.institutionDepartment of Chemistry and Biochemistry, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, Unites States
dc.contributor.institutionDepartment of Microbiology, Immunology and Molecular Genetics, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA.
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personKhashab, Niveen M.
refterms.dateFOA2017-06-03T00:00:00Z
dc.date.published-online2016-06-30
dc.date.published-print2016-10-10


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