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    High hydrostatic pressure adaptive strategies in an obligate piezophile Pyrococcus yayanosii

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    Type
    Article
    Authors
    Michoud, Gregoire cc
    Jebbar, Mohamed cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Date
    2016-06-02
    Online Publication Date
    2016-06-02
    Print Publication Date
    2016-07
    Permanent link to this record
    http://hdl.handle.net/10754/611779
    
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    Abstract
    Pyrococcus yayanosii CH1, as the first and only obligate piezophilic hyperthermophilic microorganism discovered to date, extends the physical and chemical limits of life on Earth. It was isolated from the Ashadze hydrothermal vent at 4,100 m depth. Multi-omics analyses were performed to study the mechanisms used by the cell to cope with high hydrostatic pressure variations. In silico analyses showed that the P. yayanosii genome is highly adapted to its harsh environment, with a loss of aromatic amino acid biosynthesis pathways and the high constitutive expression of the energy metabolism compared with other non-obligate piezophilic Pyrococcus species. Differential proteomics and transcriptomics analyses identified key hydrostatic pressure-responsive genes involved in translation, chemotaxis, energy metabolism (hydrogenases and formate metabolism) and Clustered Regularly Interspaced Short Palindromic Repeats sequences associated with Cellular apoptosis susceptibility proteins.
    Citation
    High hydrostatic pressure adaptive strategies in an obligate piezophile Pyrococcus yayanosii 2016, 6:27289 Scientific Reports
    Sponsors
    The authors would like to thank Didier Chevret for performing the proteomic analysis and Mickael Beauverger for help with protein extraction and gel migration. We are indebted to Helen McCombie for her helpful language improvement. This work was supported by the Agence Nationale de la Recherche (ANR-10-BLAN-1725 01-Living deep) and G.M. was supported by a PhD fellowship from the Conseil Régional de Bretagne.
    Publisher
    Springer Nature
    Journal
    Scientific Reports
    DOI
    10.1038/srep27289
    Additional Links
    http://www.nature.com/articles/srep27289
    ae974a485f413a2113503eed53cd6c53
    10.1038/srep27289
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division

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