Show simple item record

dc.contributor.advisorGojobori, Takashi
dc.contributor.authorAalismail, Nojood
dc.date.accessioned2016-05-12T06:59:13Z
dc.date.available2016-05-12T06:59:13Z
dc.date.issued2016-05
dc.identifier.doi10.25781/KAUST-PG4AV
dc.identifier.urihttp://hdl.handle.net/10754/609123
dc.description.abstractHydra is a simple freshwater solitary polyp used as a model system to study evolutionary aspects. The immune response of this organism has not been studied extensively and the immune response genes have not been identified and characterized. On the other hand, immune response has been investigated and genetic analysis has been initiated in other lower invertebrates. In the present study we took initiative to study the self/nonself recognition in hydra and its relation to the immune response. Moreover, performing phylogenetic analysis to look for annotated immune genes in hydra gave us a potential to analyze the expression of minor histocompatibility genes that have been shown to play a major role in grafting and transplantation in mammals. Here we obtained the cDNA library that shows expression of minor histocompatibility genes and confirmed that the annotated sequences in databases are actually present. In addition, grafting experiments suggested, although still preliminary, that homograft showed less rejection response than in heterograft. Involvement of possible minor histocompatibility gene orthologous in immune response was examined by qPCR.
dc.language.isoen
dc.subjectHydra
dc.subjectMinor Histocompatibility
dc.subjectImmune
dc.titleEvolutionary Analysis of Minor Histocompatibility Genes In Hydra
dc.typeThesis
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience
thesis.degree.grantorKing Abdullah University of Science and Technology
dc.contributor.committeememberPain, Arnab
dc.contributor.committeememberMineta, Katsuhiko
thesis.degree.disciplineBioscience
thesis.degree.nameMaster of Science
refterms.dateFOA2018-06-13T12:29:10Z


Files in this item

Thumbnail
Name:
Nojood Aalismail Thesis.pdf
Size:
1.554Mb
Format:
PDF
Description:
Nojood Aalismail Thesis

This item appears in the following Collection(s)

Show simple item record