• Login
    View Item 
    •   Home
    • Research
    • Book Chapters
    • View Item
    •   Home
    • Research
    • Book Chapters
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of KAUSTCommunitiesIssue DateSubmit DateThis CollectionIssue DateSubmit Date

    My Account

    Login

    Quick Links

    Open Access PolicyORCID LibguidePlumX LibguideSubmit an Item

    Statistics

    Display statistics

    Cell Surface Enzymatic Engineering-Based Approaches to Improve Cellular Therapies

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Type
    Book Chapter
    Authors
    AbuElela, Ayman cc
    Sakashita, Kosuke cc
    Merzaban, Jasmeen cc
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Date
    2014-06-07
    Online Publication Date
    2014-06-07
    Print Publication Date
    2014
    Permanent link to this record
    http://hdl.handle.net/10754/608652
    
    Metadata
    Show full item record
    Abstract
    The cell surface represents the interface between the cell and its environment. As such, the cell surface controls cell–cell interactions and functions such as adhesion and migration, and will transfer external cues to regulate processes such as survival, death, and differentiation. Redefining the cell surface by temporarily (or permanently) modifying the molecular landscape of the plasma membrane affects the way in which the cell interacts with its environment and influences the information that is relayed into the cell along downstream signaling pathways. This chapter outlines the role of key enzymes, the glycosyltransferases, in posttranslationally modifying proteins and lipids to fine-tune cells, ability to migrate. These enzymes are critical in controlling the formation of a platform structure, sialyl Lewis x (sLex), on circulating cells that plays a central role in the recognition and recruitment by selectin counter receptors on endothelial cells that line blood vessels of tissues throughout the body. By developing methods to manipulate the activity of these enzymes and hence the cell surface structures that result, treatments can be envisioned that direct the migration of therapeutic cells to specific locations throughout the body and also to inhibit metastasis of detrimental cells such as circulating tumor cells.
    Publisher
    Elsevier BV
    Journal
    Micro- and Nanoengineering of the Cell Surface
    ISBN
    978-1-4557-3146-6
    DOI
    10.1016/B978-1-4557-3146-6.00009-X
    Additional Links
    http://www.sciencedirect.com/science/article/pii/B978145573146600009X
    ae974a485f413a2113503eed53cd6c53
    10.1016/B978-1-4557-3146-6.00009-X
    Scopus Count
    Collections
    Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Book Chapters

    entitlement

     
    DSpace software copyright © 2002-2021  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service hosted by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items. For anonymous users the allowed maximum amount is 50 search results.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.