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dc.contributor.authorGhosheh, Yanal
dc.contributor.authorSeridi, Loqmane
dc.contributor.authorRyu, Tae Woo
dc.contributor.authorTakahashi, Hazuki
dc.contributor.authorOrlando, Valerio
dc.contributor.authorCarninci, Piero
dc.contributor.authorRavasi, Timothy
dc.date.accessioned2016-04-27T12:01:01Z
dc.date.available2016-04-27T12:01:01Z
dc.date.issued2016-04-26
dc.identifier.citationCharacterization of piRNAs across postnatal development in mouse brain 2016, 6:25039 Scientific Reports
dc.identifier.issn2045-2322
dc.identifier.pmid27112104
dc.identifier.doi10.1038/srep25039
dc.identifier.urihttp://hdl.handle.net/10754/607207
dc.description.abstractPIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues– where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.
dc.description.sponsorshipY.G., L.S., T.R.1, V.O. and T.R.2 are supported by King Abdullah University of Science and Technology. Research Grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) to the RIKEN Center for Life Science Technologies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.language.isoen
dc.publisherSpringer Nature
dc.relation.urlhttp://www.nature.com/articles/srep25039
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
dc.titleCharacterization of piRNAs across postnatal development in mouse brain
dc.typeArticle
dc.contributor.departmentApplied Mathematics and Computational Science Program
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentComputer Science Program
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentKAUST Environmental Epigenetics Research Program (KEEP)
dc.identifier.journalScientific Reports
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionRIKEN Center for Life Science Technologies, Division of Genomic Technologies, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
dc.contributor.institutionDepartment of Medicine, Division of Genetic, University of California, San Diego. 9500 Gilman Drive La Jolla, California 92093-0688, USA
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personGhosheh, Yanal
kaust.personSeridi, Loqmane
kaust.personRyu, Tae Woo
kaust.personOrlando, Valerio
kaust.personRavasi, Timothy
refterms.dateFOA2018-06-13T13:10:45Z
dc.date.published-online2016-04-26
dc.date.published-print2016-07


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