Characterization of piRNAs across postnatal development in mouse brain
Ryu, Tae Woo
KAUST DepartmentApplied Mathematics and Computational Science Program
KAUST Environmental Epigenetics Research Program (KEEP)
Biological and Environmental Sciences and Engineering (BESE) Division
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AbstractPIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues– where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.
CitationCharacterization of piRNAs across postnatal development in mouse brain 2016, 6:25039 Scientific Reports
SponsorsY.G., L.S., T.R.1, V.O. and T.R.2 are supported by King Abdullah University of Science and Technology. Research Grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) to the RIKEN Center for Life Science Technologies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
PublisherNature Publishing Group
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