Characterization of piRNAs across postnatal development in mouse brain
Type
ArticleAuthors
Ghosheh, Yanal
Seridi, Loqmane

Ryu, Tae Woo
Takahashi, Hazuki
Orlando, Valerio

Carninci, Piero
Ravasi, Timothy

KAUST Department
Applied Mathematics and Computational Science ProgramBiological and Environmental Sciences and Engineering (BESE) Division
Bioscience Program
Computational Bioscience Research Center (CBRC)
Computer Science Program
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
KAUST Environmental Epigenetics Research Program (KEEP)
Date
2016-04-26Online Publication Date
2016-04-26Print Publication Date
2016-07Permanent link to this record
http://hdl.handle.net/10754/607207
Metadata
Show full item recordAbstract
PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues– where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.Citation
Characterization of piRNAs across postnatal development in mouse brain 2016, 6:25039 Scientific ReportsSponsors
Y.G., L.S., T.R.1, V.O. and T.R.2 are supported by King Abdullah University of Science and Technology. Research Grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) to the RIKEN Center for Life Science Technologies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Publisher
Springer NatureJournal
Scientific ReportsPubMed ID
27112104Additional Links
http://www.nature.com/articles/srep25039ae974a485f413a2113503eed53cd6c53
10.1038/srep25039
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Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Applied Mathematics and Computational Science Program; Computer Science Program; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Science and Engineering (CEMSE) DivisionRelated articles
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