Characterization of piRNAs across postnatal development in mouse brain

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Type
Article
Authors
Ghosheh, Yanal cc
Seridi, Loqmane cc
Ryu, Tae Woo
Takahashi, Hazuki
Orlando, Valerio cc
Carninci, Piero
Ravasi, Timothy cc
KAUST Department
Applied Mathematics and Computational Science Program
KAUST Environmental Epigenetics Research Program (KEEP)
Biological and Environmental Sciences and Engineering (BESE) Division
Date
2016-04-26
Permanent link to this record
http://hdl.handle.net/10754/607207

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Abstract
PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues– where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.
Citation
Characterization of piRNAs across postnatal development in mouse brain 2016, 6:25039 Scientific Reports
Sponsors
Y.G., L.S., T.R.1, V.O. and T.R.2 are supported by King Abdullah University of Science and Technology. Research Grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) to the RIKEN Center for Life Science Technologies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher
Nature Publishing Group
Journal
Scientific Reports
ISSN
2045-2322
DOI
10.1038/srep25039
PubMed ID
27112104
Additional Links
http://www.nature.com/articles/srep25039
Collections
Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Applied Mathematics and Computational Science Program