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    Characterization of piRNAs across postnatal development in mouse brain

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    Type
    Article
    Authors
    Ghosheh, Yanal cc
    Seridi, Loqmane cc
    Ryu, Tae Woo
    Takahashi, Hazuki
    Orlando, Valerio cc
    Carninci, Piero
    Ravasi, Timothy cc
    KAUST Department
    Applied Mathematics and Computational Science Program
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Computational Bioscience Research Center (CBRC)
    Computer Science Program
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    KAUST Environmental Epigenetics Research Program (KEEP)
    Date
    2016-04-26
    Online Publication Date
    2016-04-26
    Print Publication Date
    2016-07
    Permanent link to this record
    http://hdl.handle.net/10754/607207
    
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    Abstract
    PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues– where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.
    Citation
    Characterization of piRNAs across postnatal development in mouse brain 2016, 6:25039 Scientific Reports
    Sponsors
    Y.G., L.S., T.R.1, V.O. and T.R.2 are supported by King Abdullah University of Science and Technology. Research Grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) to the RIKEN Center for Life Science Technologies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
    Publisher
    Springer Nature
    Journal
    Scientific Reports
    DOI
    10.1038/srep25039
    PubMed ID
    27112104
    Additional Links
    http://www.nature.com/articles/srep25039
    ae974a485f413a2113503eed53cd6c53
    10.1038/srep25039
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Applied Mathematics and Computational Science Program; Computer Science Program; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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