miRNA Repertoires of Demosponges Stylissa carteri and Xestospongia testudinaria
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Type
ArticleKAUST Department
Red Sea Research Center (RSRC)Biological and Environmental Sciences and Engineering (BESE) Division
Computational Bioscience Research Center (CBRC)
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Marine Science Program
Bioscience Program
KAUST Environmental Epigenetics Research Program (KEEP)
Date
2016-02-12Permanent link to this record
http://hdl.handle.net/10754/600684
Metadata
Show full item recordAbstract
MicroRNAs (miRNAs) are small regulatory RNAs that are involved in many biological process in eukaryotes. They play a crucial role in modulating genetic expression of their targets, which makes them integral components of transcriptional regulatory networks. As sponges (phylum Porifera) are commonly considered the most basal metazoan, the in-depth capture of miRNAs from these organisms provides additional clues to the evolution of miRNA families in metazoans. Here, we identified the core proteins involved in the biogenesis of miRNAs, and obtained evidence for bona fide miRNA sequences for two marine sponges Stylissa carteri and Xestospongia testudinaria (11 and 19 respectively). Our analysis identified several miRNAs that are conserved amongst demosponges, and revealed that all of the novel miRNAs identified in these two species are specific to the class Demospongiae.Citation
miRNA Repertoires of Demosponges Stylissa carteri and Xestospongia testudinaria 2016, 11 (2):e0149080 PLOS ONESponsors
We thank Annika Haywood, Feras Lafi and Holly Bream for extracting the RNA used for sequencing, as well as two anonymous reviewers for their invaluable suggestions. This project was supported by the King Abdullah University of Science and Technology (KAUST).Publisher
Public Library of Science (PLoS)Journal
PLoS ONEPubMed ID
26871907Additional Links
http://dx.plos.org/10.1371/journal.pone.0149080ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0149080
Scopus Count
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