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dc.contributor.authorDeng, Lin
dc.contributor.authorLi, Qiujin
dc.contributor.authorAl-Rehili, Safa'a
dc.contributor.authorOmar, Haneen
dc.contributor.authorAlmalik, Abdulaziz
dc.contributor.authorAlshamsan, Aws
dc.contributor.authorZhang, Jianfei
dc.contributor.authorKhashab, Niveen M.
dc.date.accessioned2016-03-03T12:22:18Z
dc.date.available2016-03-03T12:22:18Z
dc.date.issued2016-02-25
dc.identifier.citationHybrid Iron Oxide-Graphene Oxide-Polysaccharides Microcapsule: A Micro-Matryoshka for On-demand Drug Release and Antitumor Therapy In Vivo 2016 ACS Applied Materials & Interfaces
dc.identifier.issn1944-8244
dc.identifier.issn1944-8252
dc.identifier.pmid26915062
dc.identifier.doi10.1021/acsami.6b00322
dc.identifier.urihttp://hdl.handle.net/10754/600522
dc.description.abstractPremature drug release is a common drawback in stimuli responsive drug delivery systems (DDS) especially if it depends on internal triggers, that are hard to control, or a single external stimulus, that can only have one function. Thus, many DDS systems were reported combining different triggers, however limited success has been established in fine-tuning the release process mainly due to the poor bioavailability and complexity of the reported designs. This paper reports the design of a hybrid microcapsule (h-MC) by a simple layer-by-layer technique comprising polysaccharides (Alg, Chi, HA), iron oxide, and graphene oxide. Electrostatic assembly of the oppositely charged polysaccharides and graphene sheets provided a robust structure to load drugs through pH control. The polysaccharides component ensured high biocompatibility, bioavailability, and tumor cells targeting. Magnetic field and near infrared laser triggerable Fe3O4@GO component provided dual high energy and high penetration hyperthermia therapy. On-demand drug release from h-MC can be achieved by synchronizing these external triggers, making it highly controllable. The synergistic effect of hyperthermia and chemotherapy was successfully confirmed in vitro and in vivo.
dc.description.sponsorshipThis work was supported by King Abdullah University of Science and Technology (KAUST), Kingdom of Saudi Arabia, and the Natural Science Foundation of Tianjin, China (15JCYBJC18000).
dc.language.isoen
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttp://pubs.acs.org/doi/abs/10.1021/acsami.6b00322
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acsami.6b00322.
dc.titleHybrid Iron Oxide-Graphene Oxide-Polysaccharides Microcapsule: A Micro-Matryoshka for On-demand Drug Release and Antitumor Therapy In Vivo
dc.typeArticle
dc.contributor.departmentSmart Hybrid Materials (SHMs) lab
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.identifier.journalACS Applied Materials & Interfaces
dc.eprint.versionPost-print
dc.contributor.institutionSchool of Textiles, Tianjin Polytechnic University; Key Laboratory of Advanced Textile Composites (Tianjin Polytechnic University), Ministry of Education, Tianjin 300387, China
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
refterms.dateFOA2017-02-25T00:00:00Z


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