Hybrid Iron Oxide-Graphene Oxide-Polysaccharides Microcapsule: A Micro-Matryoshka for On-demand Drug Release and Antitumor Therapy In Vivo
Khashab, Niveen M.
KAUST DepartmentSmart Hybrid Materials (SHMs) lab
Advanced Membranes and Porous Materials Research Center
Permanent link to this recordhttp://hdl.handle.net/10754/600522
MetadataShow full item record
AbstractPremature drug release is a common drawback in stimuli responsive drug delivery systems (DDS) especially if it depends on internal triggers, that are hard to control, or a single external stimulus, that can only have one function. Thus, many DDS systems were reported combining different triggers, however limited success has been established in fine-tuning the release process mainly due to the poor bioavailability and complexity of the reported designs. This paper reports the design of a hybrid microcapsule (h-MC) by a simple layer-by-layer technique comprising polysaccharides (Alg, Chi, HA), iron oxide, and graphene oxide. Electrostatic assembly of the oppositely charged polysaccharides and graphene sheets provided a robust structure to load drugs through pH control. The polysaccharides component ensured high biocompatibility, bioavailability, and tumor cells targeting. Magnetic field and near infrared laser triggerable Fe3O4@GO component provided dual high energy and high penetration hyperthermia therapy. On-demand drug release from h-MC can be achieved by synchronizing these external triggers, making it highly controllable. The synergistic effect of hyperthermia and chemotherapy was successfully confirmed in vitro and in vivo.
CitationHybrid Iron Oxide-Graphene Oxide-Polysaccharides Microcapsule: A Micro-Matryoshka for On-demand Drug Release and Antitumor Therapy In Vivo 2016 ACS Applied Materials & Interfaces
SponsorsThis work was supported by King Abdullah University of Science and Technology (KAUST), Kingdom of Saudi Arabia, and the Natural Science Foundation of Tianjin, China (15JCYBJC18000).
PublisherAmerican Chemical Society (ACS)
- Graphene oxide modified PLA microcapsules containing gold nanoparticles for ultrasonic/CT bimodal imaging guided photothermal tumor therapy.
- Authors: Jin Y, Wang J, Ke H, Wang S, Dai Z
- Issue date: 2013 Jul
- Improved Anticancer Photothermal Therapy Using the Bystander Effect Enhanced by Antiarrhythmic Peptide Conjugated Dopamine-Modified Reduced Graphene Oxide Nanocomposite.
- Authors: Yu J, Lin YH, Yang L, Huang CC, Chen L, Wang WC, Chen GW, Yan J, Sawettanun S, Lin CH
- Issue date: 2017 Jan
- Functionalized graphene oxide-based thermosensitive hydrogel for near-infrared chemo-photothermal therapy on tumor.
- Authors: Zhu X, Zhang Y, Huang H, Zhang H, Hou L, Zhang Z
- Issue date: 2016 Mar
- Synergistic effect of chemo-photothermal therapy using PEGylated graphene oxide.
- Authors: Zhang W, Guo Z, Huang D, Liu Z, Guo X, Zhong H
- Issue date: 2011 Nov
- Probing suitable therapeutic nanoparticles for controlled drug delivery and diagnostic reproductive health biomarker development.
- Authors: Jha R, Jha PK, Gupta S, Bhuvaneshwaran SP, Hossain M, Guha SK
- Issue date: 2016 Apr 1