Hybrid Iron Oxide-Graphene Oxide-Polysaccharides Microcapsule: A Micro-Matryoshka for On-demand Drug Release and Antitumor Therapy In Vivo
Type
ArticleAuthors
Deng, Lin
Li, Qiujin
Al-Rehili, Safa'a
Omar, Haneen
Almalik, Abdulaziz
Alshamsan, Aws
Zhang, Jianfei
Khashab, Niveen M.

KAUST Department
Smart Hybrid Materials (SHMs) labAdvanced Membranes and Porous Materials Research Center
Date
2016-03-14Online Publication Date
2016-03-14Print Publication Date
2016-03-23Permanent link to this record
http://hdl.handle.net/10754/600522
Metadata
Show full item recordAbstract
Premature drug release is a common drawback in stimuli responsive drug delivery systems (DDS) especially if it depends on internal triggers, that are hard to control, or a single external stimulus, that can only have one function. Thus, many DDS systems were reported combining different triggers, however limited success has been established in fine-tuning the release process mainly due to the poor bioavailability and complexity of the reported designs. This paper reports the design of a hybrid microcapsule (h-MC) by a simple layer-by-layer technique comprising polysaccharides (Alg, Chi, HA), iron oxide, and graphene oxide. Electrostatic assembly of the oppositely charged polysaccharides and graphene sheets provided a robust structure to load drugs through pH control. The polysaccharides component ensured high biocompatibility, bioavailability, and tumor cells targeting. Magnetic field and near infrared laser triggerable Fe3O4@GO component provided dual high energy and high penetration hyperthermia therapy. On-demand drug release from h-MC can be achieved by synchronizing these external triggers, making it highly controllable. The synergistic effect of hyperthermia and chemotherapy was successfully confirmed in vitro and in vivo.Citation
Hybrid Iron Oxide-Graphene Oxide-Polysaccharides Microcapsule: A Micro-Matryoshka for On-demand Drug Release and Antitumor Therapy In Vivo 2016 ACS Applied Materials & InterfacesSponsors
This work was supported by King Abdullah University of Science and Technology (KAUST), Kingdom of Saudi Arabia, and the Natural Science Foundation of Tianjin, China (15JCYBJC18000).Publisher
American Chemical Society (ACS)PubMed ID
26915062Additional Links
http://pubs.acs.org/doi/abs/10.1021/acsami.6b00322ae974a485f413a2113503eed53cd6c53
10.1021/acsami.6b00322
Scopus Count
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