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    Hybrid Iron Oxide-Graphene Oxide-Polysaccharides Microcapsule: A Micro-Matryoshka for On-demand Drug Release and Antitumor Therapy In Vivo

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    Name:
    acsami2E6b00322.pdf
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    8.170Mb
    Format:
    PDF
    Description:
    Accepted Manuscript
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    Type
    Article
    Authors
    Deng, Lin cc
    Li, Qiujin
    Al-Rehili, Safa'a
    Omar, Haneen
    Almalik, Abdulaziz
    Alshamsan, Aws
    Zhang, Jianfei
    Khashab, Niveen M. cc
    KAUST Department
    Smart Hybrid Materials (SHMs) lab
    Advanced Membranes and Porous Materials Research Center
    Date
    2016-03-14
    Online Publication Date
    2016-03-14
    Print Publication Date
    2016-03-23
    Permanent link to this record
    http://hdl.handle.net/10754/600522
    
    Metadata
    Show full item record
    Abstract
    Premature drug release is a common drawback in stimuli responsive drug delivery systems (DDS) especially if it depends on internal triggers, that are hard to control, or a single external stimulus, that can only have one function. Thus, many DDS systems were reported combining different triggers, however limited success has been established in fine-tuning the release process mainly due to the poor bioavailability and complexity of the reported designs. This paper reports the design of a hybrid microcapsule (h-MC) by a simple layer-by-layer technique comprising polysaccharides (Alg, Chi, HA), iron oxide, and graphene oxide. Electrostatic assembly of the oppositely charged polysaccharides and graphene sheets provided a robust structure to load drugs through pH control. The polysaccharides component ensured high biocompatibility, bioavailability, and tumor cells targeting. Magnetic field and near infrared laser triggerable Fe3O4@GO component provided dual high energy and high penetration hyperthermia therapy. On-demand drug release from h-MC can be achieved by synchronizing these external triggers, making it highly controllable. The synergistic effect of hyperthermia and chemotherapy was successfully confirmed in vitro and in vivo.
    Citation
    Hybrid Iron Oxide-Graphene Oxide-Polysaccharides Microcapsule: A Micro-Matryoshka for On-demand Drug Release and Antitumor Therapy In Vivo 2016 ACS Applied Materials & Interfaces
    Sponsors
    This work was supported by King Abdullah University of Science and Technology (KAUST), Kingdom of Saudi Arabia, and the Natural Science Foundation of Tianjin, China (15JCYBJC18000).
    Publisher
    American Chemical Society (ACS)
    Journal
    ACS Applied Materials & Interfaces
    DOI
    10.1021/acsami.6b00322
    PubMed ID
    26915062
    Additional Links
    http://pubs.acs.org/doi/abs/10.1021/acsami.6b00322
    ae974a485f413a2113503eed53cd6c53
    10.1021/acsami.6b00322
    Scopus Count
    Collections
    Articles; Advanced Membranes and Porous Materials Research Center; Controlled Release and Delivery Laboratory

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