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dc.contributor.authorFischle, Wolfgang
dc.contributor.authorSchwarzer, Dirk
dc.date.accessioned2016-03-02T06:38:55Z
dc.date.available2016-03-02T06:38:55Z
dc.date.issued2016-02-04
dc.identifier.citationProbing Chromatin-modifying Enzymes with Chemical Tools 2016 ACS Chemical Biology
dc.identifier.issn1554-8929
dc.identifier.issn1554-8937
dc.identifier.doi10.1021/acschembio.5b01023
dc.identifier.urihttp://hdl.handle.net/10754/600475
dc.description.abstractChromatin is the universal template of genetic information in all eukaryotic organisms. Chemical modifications of the DNA-packaging histone proteins and the DNA bases are crucial signaling events in directing the use and readout of eukaryotic genomes. The enzymes that install and remove these chromatin modifications as well as the proteins that bind these marks govern information that goes beyond the sequence of DNA. Therefore, these so-called epigenetic regulators are intensively studied and represent promising drug targets in modern medicine. We summarize and discuss recent advances in the field of chemical biology that have provided chromatin research with sophisticated tools for investigating the composition, activity, and target sites of chromatin modifying enzymes and reader proteins.
dc.description.sponsorshipThis work was funded by the priority program SPP1623 of the Deutsche Forschungsgemeinschaft (W.F. and D.S., Grants: FL 1513/3-1 and SCHW 1163/4-1) as well as intramural programs of the King Abdullah University of Science and Technology (KAUST) and the Max Planck Society (W.F.).
dc.language.isoen
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttp://pubs.acs.org/doi/abs/10.1021/acschembio.5b01023
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Chemical Biology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acschembio.5b01023.
dc.titleProbing Chromatin-modifying Enzymes with Chemical Tools
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentKAUST Environmental Epigenetics Research Program (KEEP)
dc.identifier.journalACS Chemical Biology
dc.eprint.versionPost-print
dc.contributor.institutionMax Planck Institute for Biophysical Chemistry, Laboratory of Chromatin Biochemistry, Am Fassberg 11, 37077 Göttingen, Germany
dc.contributor.institutionInterfaculty Institute of Biochemistry (IFIB), University of Tübingen, Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany
dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
kaust.personFischle, Wolfgang
refterms.dateFOA2017-02-04T00:00:00Z
dc.date.published-online2016-02-04
dc.date.published-print2016-03-18


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