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    Probing Chromatin-modifying Enzymes with Chemical Tools

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    Name:
    Fischle ACS Chem Biol 2016.pdf
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    Format:
    PDF
    Description:
    Accepted Manuscript
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    Type
    Article
    Authors
    Fischle, Wolfgang cc
    Schwarzer, Dirk
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    KAUST Environmental Epigenetics Research Program (KEEP)
    Date
    2016-02-04
    Online Publication Date
    2016-02-04
    Print Publication Date
    2016-03-18
    Permanent link to this record
    http://hdl.handle.net/10754/600475
    
    Metadata
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    Abstract
    Chromatin is the universal template of genetic information in all eukaryotic organisms. Chemical modifications of the DNA-packaging histone proteins and the DNA bases are crucial signaling events in directing the use and readout of eukaryotic genomes. The enzymes that install and remove these chromatin modifications as well as the proteins that bind these marks govern information that goes beyond the sequence of DNA. Therefore, these so-called epigenetic regulators are intensively studied and represent promising drug targets in modern medicine. We summarize and discuss recent advances in the field of chemical biology that have provided chromatin research with sophisticated tools for investigating the composition, activity, and target sites of chromatin modifying enzymes and reader proteins.
    Citation
    Probing Chromatin-modifying Enzymes with Chemical Tools 2016 ACS Chemical Biology
    Sponsors
    This work was funded by the priority program SPP1623 of the Deutsche Forschungsgemeinschaft (W.F. and D.S., Grants: FL 1513/3-1 and SCHW 1163/4-1) as well as intramural programs of the King Abdullah University of Science and Technology (KAUST) and the Max Planck Society (W.F.).
    Publisher
    American Chemical Society (ACS)
    Journal
    ACS Chemical Biology
    DOI
    10.1021/acschembio.5b01023
    Additional Links
    http://pubs.acs.org/doi/abs/10.1021/acschembio.5b01023
    ae974a485f413a2113503eed53cd6c53
    10.1021/acschembio.5b01023
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program

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