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Fischle ACS Chem Biol 2016.pdf
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ArticleAuthors
Fischle, Wolfgang
Schwarzer, Dirk
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
KAUST Environmental Epigenetics Research Program (KEEP)
Date
2016-02-04Online Publication Date
2016-02-04Print Publication Date
2016-03-18Permanent link to this record
http://hdl.handle.net/10754/600475
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Chromatin is the universal template of genetic information in all eukaryotic organisms. Chemical modifications of the DNA-packaging histone proteins and the DNA bases are crucial signaling events in directing the use and readout of eukaryotic genomes. The enzymes that install and remove these chromatin modifications as well as the proteins that bind these marks govern information that goes beyond the sequence of DNA. Therefore, these so-called epigenetic regulators are intensively studied and represent promising drug targets in modern medicine. We summarize and discuss recent advances in the field of chemical biology that have provided chromatin research with sophisticated tools for investigating the composition, activity, and target sites of chromatin modifying enzymes and reader proteins.Citation
Probing Chromatin-modifying Enzymes with Chemical Tools 2016 ACS Chemical BiologySponsors
This work was funded by the priority program SPP1623 of the Deutsche Forschungsgemeinschaft (W.F. and D.S., Grants: FL 1513/3-1 and SCHW 1163/4-1) as well as intramural programs of the King Abdullah University of Science and Technology (KAUST) and the Max Planck Society (W.F.).Publisher
American Chemical Society (ACS)Journal
ACS Chemical BiologyAdditional Links
http://pubs.acs.org/doi/abs/10.1021/acschembio.5b01023ae974a485f413a2113503eed53cd6c53
10.1021/acschembio.5b01023