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dc.contributor.authorGhosh, Subhash Chandra
dc.contributor.authorLi, Cheng Chao
dc.contributor.authorZeng, Hua Chun
dc.contributor.authorNgiam, Joyce S Y
dc.contributor.authorSeayad, Abdul M.
dc.contributor.authorChen, Anqi
dc.date.accessioned2016-02-28T08:00:28Z
dc.date.available2016-02-28T08:00:28Z
dc.date.issued2014-02-06
dc.identifier.citationGhosh SC, Li CC, Zeng HC, Ngiam JSY, Seayad AM, et al. (2014) Mesoporous Niobium Oxide Spheres as an Effective Catalyst for the Transamidation of Primary Amides with Amines. Adv Synth Catal 356: 475–484. Available: http://dx.doi.org/10.1002/adsc.201300717.
dc.identifier.issn1615-4150
dc.identifier.doi10.1002/adsc.201300717
dc.identifier.urihttp://hdl.handle.net/10754/600273
dc.description.abstractMesoporous niobium oxide spheres (MNOS), conveniently prepared by a novel antisolvent precipitation approach, have been shown to be an effective catalyst for the transamidation of primary amides with amines. This novel transamidation can be efficiently carried out under solvent-free conditions and is applicable to a wide range of primary amides and amines to provide N-alkyl amides in good to excellent yields. The catalyst is highly stable and reusable. The application of this transamidation reaction has been demonstrated in the synthesis of antidepressant drug moclobemide and other druglike compounds. © 2014 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim.
dc.description.sponsorshipThis work was supported by GlaxoSmithKline (GSK), Singapore Economic Development Board (EDB) under GSK-Singapore Partnership for Green and Sustainable Manufacture, and the Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), Singapore. We thank Mr. Jeffery Ng (ICES) for carrying out the NH<INF>3</INF>-TPD analysis.
dc.publisherWiley
dc.subjectAmides
dc.subjectAmines
dc.subjectCatalysis
dc.subjectNiobium oxide
dc.subjectTransamidation
dc.titleMesoporous Niobium Oxide Spheres as an Effective Catalyst for the Transamidation of Primary Amides with Amines
dc.typeArticle
dc.identifier.journalAdvanced Synthesis & Catalysis
dc.contributor.institutionInstitute of Chemical and Engineering Sciences, Agency for Science, Technology and Research, 8 Biomedical Grove, Singapore 138665, Singapore
dc.contributor.institutionCSIR, Central Salt and Marine Chemicals Research Institute, G.B. Marg, Bhavnagar Gujarat 364002, India
dc.contributor.institutionKey Laboratory for Micro-Nano Optoelectronic Devices of Ministry of Education, Hunan University, Changsha 410082, China
kaust.personLi, Cheng Chao
kaust.personZeng, Hua Chun
kaust.grant.fundedcenterKAUST-NUS GCR Program


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