The effect of Cytochalasin D on F-Actin behavior of single-cell electroendocytosis using multi-chamber micro cell chip

Type
Conference Paper
Authors
Lin, Ran
Chang, Donald C.
Lee, Yi Kuen cc
KAUST Grant Number
SA-C0040
UK-COOI6
Date
2012-03

Metadata
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Abstract
Electroendocytosis (EED) is a pulsed-electric-field (PEF) induced endocytosis, facilitating cells uptake molecules through nanometer-sized EED vesicles. We herein investigate the effect of a chemical inhibitor, Cytochalasin D (CD) on the actin-filaments (F-Actin) behavior of single-cell EED. The CD concentration (C CD) can control the depolymerization of F-actin. A multi-chamber micro cell chip was fabricated to study the EED under different conditions. Large-scale single-cell data demonstrated EED highly depends on both electric field and C CD. © 2012 IEEE.
Citation
Lin R, Chang DC, Lee Y-K (2012) The effect of Cytochalasin D on F-Actin behavior of single-cell electroendocytosis using multi-chamber micro cell chip. 2012 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS). Available: http://dx.doi.org/10.1109/nems.2012.6196744.
Sponsors
The research was sponsored by a grant from Hong Kong Research Grants Council (Grant Ref. No. 615907) and by an award from the King Abdullah University of Science and Technology (KAUST Award No. SA-C0040/UK-COOI6).
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Journal
2012 7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)
Conference/Event name
7th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2012
ISBN
9781467311243
DOI
10.1109/nems.2012.6196744
Handle URI
http://hdl.handle.net/10754/600264
Collections
Publications Acknowledging KAUST Support