A simple method for fabricating multi-layer PDMS structures for 3D microfluidic chips
KAUST DepartmentWater Desalination and Reuse Research Center (WDRC)
Permanent link to this recordhttp://hdl.handle.net/10754/600241
MetadataShow full item record
AbstractWe report a simple methodology to fabricate PDMS multi-layer microfluidic chips. A PDMS slab was surface-treated by trichloro (1H,1H,2H,2H-perfluorooctyl) silane, and acts as a reusable transferring layer. Uniformity of the thickness of the patterned PDMS layer and the well-alignment could be achieved due to the transparency and proper flexibility of this transferring layer. Surface treatment results are confirmed by XPS and contact angle testing, while bonding forces between different layers were measured for better understanding of the transferring process. We have also designed and fabricated a few simple types of 3D PDMS chip, especially one consisting of 6 thin layers (each with thickness of 50 μm), to demonstrate the potential utilization of this technique. 3D fluorescence images were taken by a confocal microscope to illustrate the spatial characters of essential parts. This fabrication method is confirmed to be fast, simple, repeatable, low cost and possible to be mechanized for mass production. © The Royal Society of Chemistry 2010.
CitationZhang M, Wu J, Wang L, Xiao K, Wen W (2010) A simple method for fabricating multi-layer PDMS structures for 3D microfluidic chips. Lab Chip 10: 1199. Available: http://dx.doi.org/10.1039/b923101c.
SponsorsThis publication is based on work partially supported by Award No. SA-C0040/UK-C0016, made by King Abdullah University of Science and Technology (KAUST), Hong Kong RGC grants HKUST 603608. The work was also partially supported by the Nanoscience and Nanotechnology Program at HKUST. The authors would like to thank Dr Jiaxing Li and Mr Xiuqing Gong, who gave some help and good suggestion in material choosing, characterization and analyse.
PublisherRoyal Society of Chemistry (RSC)
JournalLab on a Chip
- Modification of poly(dimethylsiloxane) microfluidic channels with silica nanoparticles based on layer-by-layer assembly technique.
- Authors: Wang W, Zhao L, Zhang JR, Wang XM, Zhu JJ, Chen HY
- Issue date: 2006 Dec 8
- A simple method for preparation of macroporous polydimethylsiloxane membrane for microfluidic chip-based isoelectric focusing applications.
- Authors: Ou J, Ren CL, Pawliszyn J
- Issue date: 2010 Mar 10
- Fabricating smooth PDMS microfluidic channels from low-resolution 3D printed molds using an omniphobic lubricant-infused coating.
- Authors: Villegas M, Cetinic Z, Shakeri A, Didar TF
- Issue date: 2018 Feb 13
- Electrokinetic protein preconcentration using a simple glass/poly(dimethylsiloxane) microfluidic chip.
- Authors: Kim SM, Burns MA, Hasselbrink EF
- Issue date: 2006 Jul 15
- Fabrication and validation of a multi-channel type microfluidic chip for electrokinetic streaming potential devices.
- Authors: Chun MS, Shim MS, Choi NW
- Issue date: 2006 Feb