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    A nonlinear electromechanical coupling model for electropore expansion in cell electroporation

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    Type
    Article
    Authors
    Deng, Peigang
    Lee, Yi-Kuen cc
    Zhang, Tong Yi
    Date
    2014-10-15
    Online Publication Date
    2014-10-15
    Print Publication Date
    2014-11-05
    Permanent link to this record
    http://hdl.handle.net/10754/600240
    
    Metadata
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    Abstract
    Under an electric field, the electric tractions acting on a cell membrane containing a pore-nucleus are investigated by using a nonlinear electromechanical coupling model, in which the cell membrane is treated as a hyperelastic material. Iterations between the electric field and the structure field are performed to reveal the electrical forces exerting on the pore region and the subsequent pore expansion process. An explicit exponential decay of the membrane's edge energy as a function of pore radius is defined for a hydrophilic pore and the transition energy as a hydrophobic pore converts to a hydrophilic pore during the initial stage of pore formation is investigated. It is found that the edge energy for the creation of an electropore edge plays an important role at the atomistic scale and it determines the hydrophobic-hydrophilic transition energy barrier. Various free energy evolution paths are exhibited, depending on the applied electric field, which provides further insight towards the electroporation (EP) phenomenon. In comparison with previous EP models, the proposed model has the ability to predict the metastable point on the free energy curve that is relevant to the lipid ion channel. In addition, the proposed model can also predict the critical transmembrane potential for the activation of an effective electroporation that is in a good agreement with previously published experimental data.
    Citation
    Deng P, Lee Y-K, Zhang T-Y (2014) A nonlinear electromechanical coupling model for electropore expansion in cell electroporation. J Phys D: Appl Phys 47: 445401. Available: http://dx.doi.org/10.1088/0022-3727/47/44/445401.
    Sponsors
    This research was supported by a Hubei Natural Science Foundation grant (2012FFB04701), partially supported by Wuhan Science and Technology Bureau grant (2013010501 010145) and by Hong Kong RGC GRF Grant (16205314).
    Publisher
    IOP Publishing
    Journal
    Journal of Physics D: Applied Physics
    DOI
    10.1088/0022-3727/47/44/445401
    ae974a485f413a2113503eed53cd6c53
    10.1088/0022-3727/47/44/445401
    Scopus Count
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