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dc.contributor.authorLei, Hui
dc.contributor.authorSun, Jian Fan
dc.contributor.authorHan, Zhuang
dc.contributor.authorZhou, Xue Feng
dc.contributor.authorYang, Bin
dc.contributor.authorLiu, Yonghong
dc.date.accessioned2016-02-28T07:59:33Z
dc.date.available2016-02-28T07:59:33Z
dc.date.issued2014
dc.identifier.citationLei H, Sun J-F, Han Z, Zhou X-F, Yang B, et al. (2014) Fragilisinins A–L, new briarane-type diterpenoids from gorgonian Junceella fragilis. RSC Adv 4: 5261. Available: http://dx.doi.org/10.1039/c3ra46163g.
dc.identifier.issn2046-2069
dc.identifier.doi10.1039/c3ra46163g
dc.identifier.urihttp://hdl.handle.net/10754/600229
dc.description.abstractOur continuous study on the South China Sea gorgonian Junceella fragilis led to the isolation of twelve new briarane type diterpenoids, fragilisinins A-L (1-12), along with seven known analogues (13-19), including four naturally produced organoiodides (9-12), they are the first four iodine-containing briarane diterpenoids from this gorgonian species. Their structures were determined by MS, 1D and 2D NMR spectra analyses and by comparison with those reported in the literature. The configuration of 1 was confirmed by single-crystal X-ray diffraction data. The antifouling test showed that compounds 5, 6, 10, 13, and 15 had potent antifouling activities at nontoxic concentrations with EC50 values of 14.0, 12.6, 11.9, 5.6, and 10.0 μM, respectively. © 2014 The Royal Society of Chemistry.
dc.description.sponsorshipThis study was supported by the National Basic Research Program of China (973 Program, no. 2010CB833800 and 2011CB915503), the National High Technology Research and Development Program (863 Program, 2012AA092104), the National Natural Science Foundation of China (no. 31270402, 21172230, 20902094, 41176148, and 21002110), Guangdong Province-CAS Joint Research Program (2011B090300023 and 2012B091100264), and Guangdong Marine Economic Development and Innovation of Regional Demonstration Project (GD2012-D01-001 and GD2012-D01-002). Our thanks are due to Mr Jian-Hui Tang for his assistance in gorgonians collection.
dc.publisherRoyal Society of Chemistry (RSC)
dc.titleFragilisinins A–L, new briarane-type diterpenoids from gorgonian Junceella fragilis
dc.typeArticle
dc.identifier.journalRSC Advances
dc.contributor.institutionCAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
dc.contributor.institutionIndustrial Innovation Center for Nutrition and Health of Huzhou, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Huzhou 313000, China
dc.contributor.institutionSchool of Environment, Jiangsu University, Zhenjiang 212013, China
kaust.personHan, Zhuang
kaust.grant.programKAUST Global Partnership Program


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