Fragilisinins A–L, new briarane-type diterpenoids from gorgonian Junceella fragilis
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AbstractOur continuous study on the South China Sea gorgonian Junceella fragilis led to the isolation of twelve new briarane type diterpenoids, fragilisinins A-L (1-12), along with seven known analogues (13-19), including four naturally produced organoiodides (9-12), they are the first four iodine-containing briarane diterpenoids from this gorgonian species. Their structures were determined by MS, 1D and 2D NMR spectra analyses and by comparison with those reported in the literature. The configuration of 1 was confirmed by single-crystal X-ray diffraction data. The antifouling test showed that compounds 5, 6, 10, 13, and 15 had potent antifouling activities at nontoxic concentrations with EC50 values of 14.0, 12.6, 11.9, 5.6, and 10.0 μM, respectively. © 2014 The Royal Society of Chemistry.
CitationLei H, Sun J-F, Han Z, Zhou X-F, Yang B, et al. (2014) Fragilisinins A–L, new briarane-type diterpenoids from gorgonian Junceella fragilis. RSC Adv 4: 5261. Available: http://dx.doi.org/10.1039/c3ra46163g.
SponsorsThis study was supported by the National Basic Research Program of China (973 Program, no. 2010CB833800 and 2011CB915503), the National High Technology Research and Development Program (863 Program, 2012AA092104), the National Natural Science Foundation of China (no. 31270402, 21172230, 20902094, 41176148, and 21002110), Guangdong Province-CAS Joint Research Program (2011B090300023 and 2012B091100264), and Guangdong Marine Economic Development and Innovation of Regional Demonstration Project (GD2012-D01-001 and GD2012-D01-002). Our thanks are due to Mr Jian-Hui Tang for his assistance in gorgonians collection.
PublisherRoyal Society of Chemistry (RSC)