Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp.
| dc.contributor.author | Shao, Chang Lun | |
| dc.contributor.author | Wang, Chang Yun | |
| dc.contributor.author | Wei, Mei Yan | |
| dc.contributor.author | Gu, Yu Cheng | |
| dc.contributor.author | She, Zhi Gang | |
| dc.contributor.author | Qian, Pei-Yuan | |
| dc.contributor.author | Lin, Yong Cheng | |
| dc.date.accessioned | 2016-02-28T07:59:28Z | |
| dc.date.available | 2016-02-28T07:59:28Z | |
| dc.date.issued | 2011-01 | |
| dc.identifier.citation | Shao C-L, Wang C-Y, Wei M-Y, Gu Y-C, She Z-G, et al. (2011) Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp. Bioorganic & Medicinal Chemistry Letters 21: 690–693. Available: http://dx.doi.org/10.1016/j.bmcl.2010.12.005. | |
| dc.identifier.issn | 0960-894X | |
| dc.identifier.pmid | 21194945 | |
| dc.identifier.doi | 10.1016/j.bmcl.2010.12.005 | |
| dc.identifier.uri | http://hdl.handle.net/10754/600226 | |
| dc.description.abstract | Two novel benzylazaphilone derivatives with an unprecedented carbon skeleton, aspergilone A (1), and its symmetrical dimer with a unique methylene bridge, aspergilone B (2), have been isolated from the culture broth of a marine-derived fungus Aspergillus sp. from a gorgonian Dichotella gemmacea. Their structures and relative stereochemistries of 1 and 2 were elucidated using a combination of NMR spectroscopy and X-ray crystallography. Compound 1 not only exhibited in vitro selective cytotoxicity but also showed potent antifouling activity. © 2010 Elsevier Ltd. All rights reserved. | |
| dc.description.sponsorship | This work was supported by the National Natural Science Foundation of China (Nos. 30901879; 40976077; 40776073), the Research Fund for the Doctoral Program of Higher Education, Ministry of Education of China (No. 20090132110002), and the Basic Research Program of Science and Technology, Ministry of Science and Technology of China (No. 2007FY210500). | |
| dc.publisher | Elsevier BV | |
| dc.subject | Antifouling activity | |
| dc.subject | Aspergillus sp. | |
| dc.subject | Aspergilone | |
| dc.subject | Cytotoxicity | |
| dc.subject | Gorgonian Dichotella gemmacea | |
| dc.subject | Marine-derived fungus | |
| dc.subject | X-ray analysis | |
| dc.title | Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp. | |
| dc.type | Article | |
| dc.identifier.journal | Bioorganic & Medicinal Chemistry Letters | |
| dc.contributor.institution | Key Laboratory of Marine Drugs, Ocean University of China, Ministry of Education of China, Qingdao 266003, China | |
| dc.contributor.institution | School of Pharmacy, Guangdong Medical College, Dongguan 523808, China | |
| dc.contributor.institution | Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom | |
| dc.contributor.institution | School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China | |
| kaust.person | Qian, Pei-Yuan | |
| kaust.grant.program | KAUST Global Partnership Program |