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dc.contributor.authorShao, Chang Lun
dc.contributor.authorWang, Chang Yun
dc.contributor.authorWei, Mei Yan
dc.contributor.authorGu, Yu Cheng
dc.contributor.authorShe, Zhi Gang
dc.contributor.authorQian, Pei-Yuan
dc.contributor.authorLin, Yong Cheng
dc.date.accessioned2016-02-28T07:59:28Z
dc.date.available2016-02-28T07:59:28Z
dc.date.issued2011-01
dc.identifier.citationShao C-L, Wang C-Y, Wei M-Y, Gu Y-C, She Z-G, et al. (2011) Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp. Bioorganic & Medicinal Chemistry Letters 21: 690–693. Available: http://dx.doi.org/10.1016/j.bmcl.2010.12.005.
dc.identifier.issn0960-894X
dc.identifier.pmid21194945
dc.identifier.doi10.1016/j.bmcl.2010.12.005
dc.identifier.urihttp://hdl.handle.net/10754/600226
dc.description.abstractTwo novel benzylazaphilone derivatives with an unprecedented carbon skeleton, aspergilone A (1), and its symmetrical dimer with a unique methylene bridge, aspergilone B (2), have been isolated from the culture broth of a marine-derived fungus Aspergillus sp. from a gorgonian Dichotella gemmacea. Their structures and relative stereochemistries of 1 and 2 were elucidated using a combination of NMR spectroscopy and X-ray crystallography. Compound 1 not only exhibited in vitro selective cytotoxicity but also showed potent antifouling activity. © 2010 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipThis work was supported by the National Natural Science Foundation of China (Nos. 30901879; 40976077; 40776073), the Research Fund for the Doctoral Program of Higher Education, Ministry of Education of China (No. 20090132110002), and the Basic Research Program of Science and Technology, Ministry of Science and Technology of China (No. 2007FY210500).
dc.publisherElsevier BV
dc.subjectAntifouling activity
dc.subjectAspergillus sp.
dc.subjectAspergilone
dc.subjectCytotoxicity
dc.subjectGorgonian Dichotella gemmacea
dc.subjectMarine-derived fungus
dc.subjectX-ray analysis
dc.titleAspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp.
dc.typeArticle
dc.identifier.journalBioorganic & Medicinal Chemistry Letters
dc.contributor.institutionKey Laboratory of Marine Drugs, Ocean University of China, Ministry of Education of China, Qingdao 266003, China
dc.contributor.institutionSchool of Pharmacy, Guangdong Medical College, Dongguan 523808, China
dc.contributor.institutionSyngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire RG42 6EY, United Kingdom
dc.contributor.institutionSchool of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
kaust.personQian, Pei-Yuan
kaust.grant.programKAUST Global Partnership Program


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