Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp.
Type
ArticleAuthors
Shao, Chang LunWang, Chang Yun
Wei, Mei Yan
Gu, Yu Cheng
She, Zhi Gang
Qian, Pei-Yuan

Lin, Yong Cheng
Date
2011-01Permanent link to this record
http://hdl.handle.net/10754/600226
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Two novel benzylazaphilone derivatives with an unprecedented carbon skeleton, aspergilone A (1), and its symmetrical dimer with a unique methylene bridge, aspergilone B (2), have been isolated from the culture broth of a marine-derived fungus Aspergillus sp. from a gorgonian Dichotella gemmacea. Their structures and relative stereochemistries of 1 and 2 were elucidated using a combination of NMR spectroscopy and X-ray crystallography. Compound 1 not only exhibited in vitro selective cytotoxicity but also showed potent antifouling activity. © 2010 Elsevier Ltd. All rights reserved.Citation
Shao C-L, Wang C-Y, Wei M-Y, Gu Y-C, She Z-G, et al. (2011) Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp. Bioorganic & Medicinal Chemistry Letters 21: 690–693. Available: http://dx.doi.org/10.1016/j.bmcl.2010.12.005.Sponsors
This work was supported by the National Natural Science Foundation of China (Nos. 30901879; 40976077; 40776073), the Research Fund for the Doctoral Program of Higher Education, Ministry of Education of China (No. 20090132110002), and the Basic Research Program of Science and Technology, Ministry of Science and Technology of China (No. 2007FY210500).Publisher
Elsevier BVPubMed ID
21194945ae974a485f413a2113503eed53cd6c53
10.1016/j.bmcl.2010.12.005
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