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    Potent Antifouling Marine Dihydroquinolin-2(1H)-one-Containing Alkaloids from the Gorgonian Coral-Derived Fungus Scopulariopsis sp.

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    Type
    Article
    Authors
    Shao, Chang Lun
    Xu, Ru Fang
    Wang, Chang Yun
    Qian, Pei-Yuan cc
    Wang, Kai Ling
    Wei, Mei Yan
    Date
    2015-04-02
    Online Publication Date
    2015-04-02
    Print Publication Date
    2015-08
    Permanent link to this record
    http://hdl.handle.net/10754/600220
    
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    Abstract
    Marine biofouling has a major economic impact, especially when it occurs on ship hulls or aquaculture facilities. Since the International Maritime Organization (IMO) treaty to ban the application of organotin-based paints to ships went into effect in 2008, there is an urgent demand for the development of efficient and environmentally friendly antifouling agents. Marine microorganisms have proved to be a potential source of antifouling natural compounds. In this study, six dihydroquinolin-2-one-containing alkaloids, three monoterpenoids combined with a 4-phenyl-3,4-dihydroquinolin-2(1H)-one (1–3) and three 4-phenyl-3,4-dihydroquinolin-2(1H)-one alkaloids (4–6), were isolated from the gorgonian coral-derived fungus Scopulariopsis sp. collected in the South China Sea. These dihydroquinolin-2-one-containing alkaloids were evaluated against the larval settlement of barnacle Balanus amphitrite, and antifouling activity was detected for the first time for this class of metabolites. All of them except 6 showed strong antifouling activity. Compounds 1 and 2 were discovered to be the most promising non-toxic antilarval settlement candidates. Especially, compound 1 is the strongest antifouling compound in nature until now which showed highly potent activity with picomolar level (EC50 17.5 pM) and a very safety and high therapeutic ratio (LC50/EC50 1200). This represents an effective non-toxic, anti-larval settlement structural class of promising antifouling lead compound. © 2015 Springer Science+Business Media New York
    Citation
    Shao C-L, Xu R-F, Wang C-Y, Qian P-Y, Wang K-L, et al. (2015) Potent Antifouling Marine Dihydroquinolin-2(1H)-one-Containing Alkaloids from the Gorgonian Coral-Derived Fungus Scopulariopsis sp. Mar Biotechnol 17: 408–415. Available: http://dx.doi.org/10.1007/s10126-015-9628-x.
    Sponsors
    We would like to thank Prof. Z.-G She and Y. Xu for their useful discussion. This work was supported by the Program of National Natural Science Foundation of China (Nos. 41322037, 41176121, and 41130858), and the Program for New Century Excellent Talents in University, Ministry of Education of China (No. NCET-11-0472).
    Publisher
    Springer Nature
    Journal
    Marine Biotechnology
    DOI
    10.1007/s10126-015-9628-x
    PubMed ID
    25833409
    ae974a485f413a2113503eed53cd6c53
    10.1007/s10126-015-9628-x
    Scopus Count
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